| pubmed-article:12531901 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12531901 | lifeskim:mentions | umls-concept:C0061928 | lld:lifeskim |
| pubmed-article:12531901 | lifeskim:mentions | umls-concept:C0080093 | lld:lifeskim |
| pubmed-article:12531901 | lifeskim:mentions | umls-concept:C1514762 | lld:lifeskim |
| pubmed-article:12531901 | lifeskim:mentions | umls-concept:C1366537 | lld:lifeskim |
| pubmed-article:12531901 | lifeskim:mentions | umls-concept:C1419227 | lld:lifeskim |
| pubmed-article:12531901 | lifeskim:mentions | umls-concept:C1837895 | lld:lifeskim |
| pubmed-article:12531901 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:12531901 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:12531901 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:12531901 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:12531901 | pubmed:dateCreated | 2003-3-10 | lld:pubmed |
| pubmed-article:12531901 | pubmed:abstractText | Cadherin adhesion molecules are believed to be important for synaptic plasticity. beta-Catenin, which links cadherins and the actin cytoskeleton, is a modulator of cadherin adhesion and regulates synaptic structure and function. Here we show that beta-catenin interacts with a novel GTPase-activating protein, named RICS, that acts on Cdc42 and Rac1. The RICS-beta-catenin complex was found to be associated with N-cadherin, N-methyl-d-aspartate receptors, and postsynaptic density-95, and localized to the postsynaptic density. Furthermore, the GTPase-activating protein activity of RICS was inhibited by phosphorylation by Ca(2+)/calmodulin-dependent protein kinase II. These results suggest that RICS is involved in the synaptic adhesion- and N-methyl-d-aspartate-mediated organization of cytoskeletal networks and signal transduction. Thus, RICS may regulate dendritic spine morphology and strength by modulating Rho GTPases. | lld:pubmed |
| pubmed-article:12531901 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12531901 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12531901 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12531901 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12531901 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12531901 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12531901 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12531901 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12531901 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12531901 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12531901 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12531901 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12531901 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12531901 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12531901 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12531901 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12531901 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12531901 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12531901 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12531901 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12531901 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12531901 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12531901 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12531901 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12531901 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:12531901 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:12531901 | pubmed:author | pubmed-author:NakamuraTsuto... | lld:pubmed |
| pubmed-article:12531901 | pubmed:author | pubmed-author:OhwadaSusumuS | lld:pubmed |
| pubmed-article:12531901 | pubmed:author | pubmed-author:MorishitaYasu... | lld:pubmed |
| pubmed-article:12531901 | pubmed:author | pubmed-author:AkiyamaTetsuT | lld:pubmed |
| pubmed-article:12531901 | pubmed:author | pubmed-author:KohuKazuyoshi... | lld:pubmed |
| pubmed-article:12531901 | pubmed:author | pubmed-author:OkabeToshioT | lld:pubmed |
| pubmed-article:12531901 | pubmed:author | pubmed-author:NishimuraYuki... | lld:pubmed |
| pubmed-article:12531901 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12531901 | pubmed:day | 14 | lld:pubmed |
| pubmed-article:12531901 | pubmed:volume | 278 | lld:pubmed |
| pubmed-article:12531901 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12531901 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12531901 | pubmed:pagination | 9920-7 | lld:pubmed |
| pubmed-article:12531901 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:12531901 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12531901 | pubmed:articleTitle | RICS, a novel GTPase-activating protein for Cdc42 and Rac1, is involved in the beta-catenin-N-cadherin and N-methyl-D-aspartate receptor signaling. | lld:pubmed |
| pubmed-article:12531901 | pubmed:affiliation | Laboratory of Molecular and Genetic Information, Institute for Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan. | lld:pubmed |
| pubmed-article:12531901 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12531901 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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