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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2003-1-17
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pubmed:abstractText |
We have made xeroderma pigmentosum group A gene (XPA)-knockout mice (XPA(-/-) mice). The XPA(-/-) mice had no detectable activity for nucleotide excision repair (NER) and showed a high incidence of UVB-induced skin tumorigenesis. We have also found that cell lines derived from skin cancers in UVB-irradiated XPA(-/-) mice become tolerant to UV-irradiation and showed abnormal UV-induced cell cycle checkpoints and decreased mismatch repair (MMR) activity. These results suggested that the MMR-downregulation may help cells escape killing by UV-irradiation and thus MMR-deficient clones are selected for during the tumorigenic transformation of XPA(-/-) cells. In this report, we examined whether the incidence of UVB-induced skin tumorigenesis is enhanced in XPA(-/-)MSH2(-/-), XPA(-/-) and MSH2(-/-) mice when compared with that in wild-type mice. Our results indicate that the MSH2-deficiency caused a high incidence of spontaneous and UVB-induced skin tumorigenesis and the XPA and MSH2 genes have additive roles in the UV-induced skin tumorigenesis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1568-7864
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
3
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pubmed:volume |
1
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
935-40
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12531021-Animals,
pubmed-meshheading:12531021-Cell Survival,
pubmed-meshheading:12531021-Cells, Cultured,
pubmed-meshheading:12531021-DNA Repair,
pubmed-meshheading:12531021-DNA-Binding Proteins,
pubmed-meshheading:12531021-Genetic Predisposition to Disease,
pubmed-meshheading:12531021-Mice,
pubmed-meshheading:12531021-Mice, Knockout,
pubmed-meshheading:12531021-MutS Homolog 2 Protein,
pubmed-meshheading:12531021-Neoplasms, Radiation-Induced,
pubmed-meshheading:12531021-Proto-Oncogene Proteins,
pubmed-meshheading:12531021-Skin,
pubmed-meshheading:12531021-Skin Neoplasms,
pubmed-meshheading:12531021-Survival Rate,
pubmed-meshheading:12531021-Ultraviolet Rays,
pubmed-meshheading:12531021-Xeroderma Pigmentosum Group A Protein
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pubmed:year |
2002
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pubmed:articleTitle |
Additive roles of XPA and MSH2 genes in UVB-induced skin tumorigenesis in mice.
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pubmed:affiliation |
Laboratories of Organismal Biosystems, Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamadaoka, Suita, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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