|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
2003-1-17
|
|
pubmed:abstractText |
Two melanocortin receptors MC2-R (ACTH-receptor) and MC5-R are expressed in the adult lamb adrenal cortex. In this work, we have studied the time-course of expression of these two receptors during ovine fetal development. MC2-R expression progressively increases from day 60 to day 140 of gestation (x3), then more rapidly before parturition and remains constant in the newborn. In contrast, the pattern of MC5-R expression is totally different. A strong increase is observed between days 60 and 120 (x7) then followed by a decrease until parturition and after birth. This peak of MC5-R expression precedes that of MC2-R, suggesting that MC5-R might be involved in alpha-MSH- and/or ACTH-stimulated corticosteroid synthesis during early embryonic life.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
0743-5800
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
28
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
631-5
|
|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:12530674-Adrenal Glands,
pubmed-meshheading:12530674-Animals,
pubmed-meshheading:12530674-Animals, Newborn,
pubmed-meshheading:12530674-Embryonic and Fetal Development,
pubmed-meshheading:12530674-RNA, Messenger,
pubmed-meshheading:12530674-Receptor, Melanocortin, Type 2,
pubmed-meshheading:12530674-Receptors, Corticotropin,
pubmed-meshheading:12530674-Receptors, Melanocortin,
pubmed-meshheading:12530674-Sheep
|
|
pubmed:year |
2002
|
|
pubmed:articleTitle |
Expression of the melanocortin receptors MC2-R (ACTH-receptor) and MC5-R during embryonic development of ovine adrenals.
|
|
pubmed:affiliation |
Institute of Histology, Faculty of Medicine, Porto, Portugal.
|
|
pubmed:publicationType |
Journal Article
|
