Linked Life Data

12521926

Source:http://linkedlifedata.com/resource/pubmed/id/12521926

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2003-4-4
pubmed:abstractText
Recent studies suggest that the mesoaccumbens dopamine system undergoes neurochemical alterations as a result of restricted feeding conditions with access to sugars. This effect appears to be similar to the neuroadaptation resulting from drugs of abuse and may underlay some pathological feeding behaviors. To further investigate the cellular mechanisms of these alterations, the present study used quantitative autoradiography and in situ hybridization to assess dopamine membrane transporter (DAT) protein density and mRNA expression in restricted-fed and free-fed adult male rats. The restricted feeding regimen consisted of daily limited access to either a normally preferred sucrose solution (0.3 M) or a less preferred chow in a scheduled (i.e., contingent) fashion for 7 days. Restricted-fed rats with the contingent sucrose access lost less body weight, ate more total food, and drank more fluid than free-fed, contingent food, or noncontingent controls. In addition, these animals had selectively higher DAT binding in the nucleus accumbens and ventral tegmental area. This increase in protein binding also was accompanied by an increase in DAT mRNA levels in the ventral tegmental area. In contrast to the restricted-fed groups, no differential effect in DAT regulation was observed across free-fed groups. The observed alteration in behavior and DAT regulation suggest that neuroadaptation in the mesoaccumbens dopamine system develops in response to repeated feeding on palatable foods under dietary constraints. This supports the notion that similar cellular changes may be involved in restrictive eating disorders and bingeing.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0363-6119
pubmed:author
pubmed:issnType
Print
pubmed:volume
284
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
R1260-8
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:12521926-Animals, pubmed-meshheading:12521926-Blood Glucose, pubmed-meshheading:12521926-Corticosterone, pubmed-meshheading:12521926-Diet, pubmed-meshheading:12521926-Dopamine Plasma Membrane Transport Proteins, pubmed-meshheading:12521926-Drinking, pubmed-meshheading:12521926-Eating, pubmed-meshheading:12521926-Food Deprivation, pubmed-meshheading:12521926-Insulin, pubmed-meshheading:12521926-Male, pubmed-meshheading:12521926-Membrane Glycoproteins, pubmed-meshheading:12521926-Membrane Transport Proteins, pubmed-meshheading:12521926-Nerve Tissue Proteins, pubmed-meshheading:12521926-RNA, Messenger, pubmed-meshheading:12521926-Rats, pubmed-meshheading:12521926-Rats, Sprague-Dawley, pubmed-meshheading:12521926-Sucrose, pubmed-meshheading:12521926-Time Factors, pubmed-meshheading:12521926-Up-Regulation
pubmed:year
2003
pubmed:articleTitle
Restricted feeding with scheduled sucrose access results in an upregulation of the rat dopamine transporter.
pubmed:affiliation
Departments of Behavioral Science and of Pharmacology, Neuroscience Graduate Program, Integrative Biosciences Graduate Program, The Pennsylvania State University, College of Medicine, Hershey, Pennsylvania 17033, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.