Linked Life Data

12520087

Source:http://linkedlifedata.com/resource/pubmed/id/12520087

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2003-1-9
pubmed:abstractText
Insulin receptor substrate proteins (IRS) mediate various effects of insulin, including regulation of glucose homeostasis, cell growth and survival. To understand the underlying mechanisms explaining the effects of the Src-related tyrosine kinase GTK on beta-cell proliferation and survival, insulin-signalling pathways involving IRS-1 and IRS-2 were studied in islet cells and RINm5F cells overexpressing wild-type and two different mutants of the SRC-related tyrosine kinase GTK.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Akt1 protein, rat, http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers, http://linkedlifedata.com/resource/pubmed/chemical/Insulin, http://linkedlifedata.com/resource/pubmed/chemical/Insulin Receptor Substrate Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Insulin-Like Growth Factor I, http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides..., http://linkedlifedata.com/resource/pubmed/chemical/Irs1 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Irs1 protein, rat, http://linkedlifedata.com/resource/pubmed/chemical/Irs2 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Irs2 protein, rat, http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 1, http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 3, http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases, http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylinositol 3-Kinases, http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins, http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases, http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases, http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-akt, http://linkedlifedata.com/resource/pubmed/chemical/Shb protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Shb protein, rat, http://linkedlifedata.com/resource/pubmed/chemical/gtk kinase
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1076-1551
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
705-13
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:12520087-Animals, pubmed-meshheading:12520087-Apoptosis, pubmed-meshheading:12520087-Blotting, Western, pubmed-meshheading:12520087-COS Cells, pubmed-meshheading:12520087-Cell Division, pubmed-meshheading:12520087-Cells, Cultured, pubmed-meshheading:12520087-Cercopithecus aethiops, pubmed-meshheading:12520087-DNA Primers, pubmed-meshheading:12520087-Flow Cytometry, pubmed-meshheading:12520087-Insulin, pubmed-meshheading:12520087-Insulin Receptor Substrate Proteins, pubmed-meshheading:12520087-Insulin-Like Growth Factor I, pubmed-meshheading:12520087-Intracellular Signaling Peptides and Proteins, pubmed-meshheading:12520087-Islets of Langerhans, pubmed-meshheading:12520087-Mice, pubmed-meshheading:12520087-Mice, Inbred CBA, pubmed-meshheading:12520087-Mice, Transgenic, pubmed-meshheading:12520087-Mitogen-Activated Protein Kinase 1, pubmed-meshheading:12520087-Mitogen-Activated Protein Kinase 3, pubmed-meshheading:12520087-Mitogen-Activated Protein Kinases, pubmed-meshheading:12520087-Mutation, pubmed-meshheading:12520087-Phosphatidylinositol 3-Kinases, pubmed-meshheading:12520087-Phosphoproteins, pubmed-meshheading:12520087-Promoter Regions, Genetic, pubmed-meshheading:12520087-Protein-Serine-Threonine Kinases, pubmed-meshheading:12520087-Protein-Tyrosine Kinases, pubmed-meshheading:12520087-Proto-Oncogene Proteins, pubmed-meshheading:12520087-Proto-Oncogene Proteins c-akt, pubmed-meshheading:12520087-Rats, pubmed-meshheading:12520087-Signal Transduction, pubmed-meshheading:12520087-Transfection
pubmed:year
2002
pubmed:articleTitle
GTK tyrosine kinase-induced alteration of IRS-protein signalling in insulin producing cells.
pubmed:affiliation
Department of Medical Cell Biology, Uppsala University, Sweden.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't