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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2003-1-9
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pubmed:abstractText |
The ProtoNet site provides an automatic hierarchical clustering of the SWISS-PROT protein database. The clustering is based on an all-against-all BLAST similarity search. The similarities' E-score is used to perform a continuous bottom-up clustering process by applying alternative rules for merging clusters. The outcome of this clustering process is a classification of the input proteins into a hierarchy of clusters of varying degrees of granularity. ProtoNet (version 1.3) is accessible in the form of an interactive web site at http://www.protonet.cs.huji.ac.il. ProtoNet provides navigation tools for monitoring the clustering process with a vertical and horizontal view. Each cluster at any level of the hierarchy is assigned with a statistical index, indicating the level of purity based on biological keywords such as those provided by SWISS-PROT and InterPro. ProtoNet can be used for function prediction, for defining superfamilies and subfamilies and for large-scale protein annotation purposes.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/12520020-10591097,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12520020-10592169,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12520020-10592178,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12520020-10592179,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12520020-10592232,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12520020-10592234,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12520020-10592235,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12520020-10592242,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12520020-10592243,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12520020-10592244,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12520020-10792051,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12520020-11125042,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12520020-11125043,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12520020-11294792,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12520020-11406384,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12520020-12117787,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12520020-12169526,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12520020-9847184
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1362-4962
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
31
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
348-52
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
2003
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pubmed:articleTitle |
ProtoNet: hierarchical classification of the protein space.
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pubmed:affiliation |
School of Computer Science and Engineering, Institute of Life Sciences, The Hebrew University, Jerusalem 91904, Israel.
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pubmed:publicationType |
Journal Article
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