Linked Life Data

12517722

Source:http://linkedlifedata.com/resource/pubmed/id/12517722

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2003-1-8
pubmed:abstractText
Mitochondria not only provide most of the ATP needed for cell work and numerous specific anabolic and catabolic functions, they also contribute to Ca++ signalling and play a key role in the pathway to cell death. Impairment of mitochondrial functions caused by mutations of the mt-genome or by acute processes, is responsible for numerous diseases. Decreased concentrations of adenine nucleotides, leaky outer and inner mitochondrial membranes, and decreased activities of respiratory chain enzymes contribute to depression of cellular energy metabolism, one of the most important consequences of mitochondrial impairment as characterized by decreased cytosolic phosphorylation potentials.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1148-5493
pubmed:author
pubmed:issnType
Print
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
395-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Energetic depression caused by mitochondrial dysfunction.
pubmed:affiliation
Muskellabor der Neurologischen Klinik, Martin-Luther-Universität Halle-Wittenberg, Germany. frank.gellerich@medizin.uni-halle.de
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't