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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2003-1-7
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pubmed:abstractText |
Cytosine deaminase (CD) activates prodrug 5-FC to 5-FU and is used for suicide gene therapy (the CD/5-FC system). E. coli uracil phosphoribosyltransferase (UPRT) is a pyrimidine salvage enzyme that directly converts 5-FU into 5-fluorouridine monophosphate and improves the antitumoral effect of 5-FU. This study demonstrates the effectiveness of transduction of the UPRT gene in addition to CD/5-FC cancer suicide gene therapy.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1099-498X
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pubmed:author |
pubmed-author:EgawaMasayukiM,
pubmed-author:HamadaHirohumiH,
pubmed-author:HoriOsamuO,
pubmed-author:KatohHiroakiH,
pubmed-author:KitagawaYasuhideY,
pubmed-author:KonakaHiroyukiH,
pubmed-author:KoshidaKiyoshiK,
pubmed-author:MiyagiTohruT,
pubmed-author:MizokamiAtsushiA,
pubmed-author:NamikiMikioM,
pubmed-author:OgawaSatoshiS
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pubmed:copyrightInfo |
Copyright 2002 John Wiley & Sons, Ltd.
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pubmed:issnType |
Print
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
30-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12516049-Adenoviridae,
pubmed-meshheading:12516049-Animals,
pubmed-meshheading:12516049-Antimetabolites, Antineoplastic,
pubmed-meshheading:12516049-Cell Line,
pubmed-meshheading:12516049-Cytosine Deaminase,
pubmed-meshheading:12516049-Fluorouracil,
pubmed-meshheading:12516049-Gene Therapy,
pubmed-meshheading:12516049-Genetic Vectors,
pubmed-meshheading:12516049-Humans,
pubmed-meshheading:12516049-Male,
pubmed-meshheading:12516049-Mice,
pubmed-meshheading:12516049-Mice, Inbred BALB C,
pubmed-meshheading:12516049-Mice, Nude,
pubmed-meshheading:12516049-Nucleoside Deaminases,
pubmed-meshheading:12516049-Pentosyltransferases,
pubmed-meshheading:12516049-Prostatic Neoplasms
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pubmed:year |
2003
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pubmed:articleTitle |
Gene therapy for prostate cancer using the cytosine deaminase/uracil phosphoribosyltransferase suicide system.
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pubmed:affiliation |
Department of Urology, Kanazawa University School of Medicine, Kanazawa, Japan.
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pubmed:publicationType |
Journal Article
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