Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2002-12-31
pubmed:abstractText
Brain angiogenesis inhibitors (BAI) are putative transmembrane proteins containing an extracellular domain with thrombospondin type-1 repeats which can exhibit anti-angiogenic activity. BAI1 mRNA is expressed mainly in the brain, while BAI2 and BAI3 mRNAs are more widely expressed. We hypothesized that the BAI family might have anti-tumoral properties and studied the expression of BAI1 protein in normal human brain and in glioblastoma multiforme. We generated an anti-BAI1 antibody and showed that BAI1 was widely expressed in normal brain but was absent in 28 glioma cell lines and in the majority of human glioblastoma investigated. BAI1 expression did not correlate with TP53 status and we did not confirm previous findings that p53 regulates BAI1 mRNA expression in glioma cells. The finding that expression of BAI proteins may be lost during tumor formation is of special interest as restoration of their function in tumors may be of therapeutic benefit.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/12507886-10416987, http://linkedlifedata.com/resource/pubmed/commentcorrection/12507886-10568831, http://linkedlifedata.com/resource/pubmed/commentcorrection/12507886-10639598, http://linkedlifedata.com/resource/pubmed/commentcorrection/12507886-10728706, http://linkedlifedata.com/resource/pubmed/commentcorrection/12507886-10811871, http://linkedlifedata.com/resource/pubmed/commentcorrection/12507886-10841526, http://linkedlifedata.com/resource/pubmed/commentcorrection/12507886-10984493, http://linkedlifedata.com/resource/pubmed/commentcorrection/12507886-11172604, http://linkedlifedata.com/resource/pubmed/commentcorrection/12507886-11193045, http://linkedlifedata.com/resource/pubmed/commentcorrection/12507886-11238026, http://linkedlifedata.com/resource/pubmed/commentcorrection/12507886-11530335, http://linkedlifedata.com/resource/pubmed/commentcorrection/12507886-11668476, http://linkedlifedata.com/resource/pubmed/commentcorrection/12507886-11875720, http://linkedlifedata.com/resource/pubmed/commentcorrection/12507886-12074842, http://linkedlifedata.com/resource/pubmed/commentcorrection/12507886-12082608, http://linkedlifedata.com/resource/pubmed/commentcorrection/12507886-2143581, http://linkedlifedata.com/resource/pubmed/commentcorrection/12507886-7531056, http://linkedlifedata.com/resource/pubmed/commentcorrection/12507886-9393972, http://linkedlifedata.com/resource/pubmed/commentcorrection/12507886-9467957, http://linkedlifedata.com/resource/pubmed/commentcorrection/12507886-9533023, http://linkedlifedata.com/resource/pubmed/commentcorrection/12507886-9647739, http://linkedlifedata.com/resource/pubmed/commentcorrection/12507886-9790924
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0002-9440
pubmed:author
pubmed:issnType
Print
pubmed:volume
162
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
19-27
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed-meshheading:12507886-Angiogenesis Inhibitors, pubmed-meshheading:12507886-Angiogenic Proteins, pubmed-meshheading:12507886-Antibody Specificity, pubmed-meshheading:12507886-Blotting, Western, pubmed-meshheading:12507886-Brain, pubmed-meshheading:12507886-Brain Neoplasms, pubmed-meshheading:12507886-DNA Mutational Analysis, pubmed-meshheading:12507886-Gene Expression Regulation, Neoplastic, pubmed-meshheading:12507886-Glioblastoma, pubmed-meshheading:12507886-Glioma, pubmed-meshheading:12507886-Humans, pubmed-meshheading:12507886-Immunohistochemistry, pubmed-meshheading:12507886-Mutation, pubmed-meshheading:12507886-Proteins, pubmed-meshheading:12507886-RNA, Messenger, pubmed-meshheading:12507886-Reverse Transcriptase Polymerase Chain Reaction, pubmed-meshheading:12507886-Transfection, pubmed-meshheading:12507886-Tumor Cells, Cultured, pubmed-meshheading:12507886-Tumor Suppressor Protein p53
pubmed:year
2003
pubmed:articleTitle
Brain angiogenesis inhibitor 1 is differentially expressed in normal brain and glioblastoma independently of p53 expression.
pubmed:affiliation
Laboratory of Molecular Neuro-Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia 30322, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't