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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2002-12-27
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pubmed:abstractText |
Human Epstein-Barr virus-immortalized lymphoblastoid B-cell lines tested positive by PCR for simian virus 40 (SV40) DNA (22 of 42 cell lines, 52.3%). B lymphocytes or tissues from which B-cell lines derived were also SV40 positive. In situ hybridization showed that SV40 DNA was present in the nucleus of a small fraction (1/250) of cells. SV40 T-antigen mRNA was detected by reverse transcription-PCR. Lymphoblastoid B-cell lines (n = 4) infected with SV40 remained SV40 positive for 4 to 6 months. SV40-positive B-cell lines were more tumorigenic in SCID mice than were SV40-negative cell lines (4 of 5 [80%] SV40-positive cell lines versus 2 of 4 [50%] SV40-negative cell lines). These results suggest that SV40 may play a role in the early phases of human lymphomagenesis.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/12502874-10817503,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12502874-11040135,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12502874-11121863,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12502874-11243899,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12502874-11572935,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12502874-11832678,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12502874-11897278,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12502874-11897287,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12502874-11920474,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12502874-1312224,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12502874-2164739,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12502874-8248262,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12502874-8841004,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12502874-9520997,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12502874-9557293,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12502874-9557685,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12502874-9584955,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12502874-9833757,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12502874-9923853,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12502874-9935206
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
77
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1595-7
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:12502874-Animals,
pubmed-meshheading:12502874-Antigens, Polyomavirus Transforming,
pubmed-meshheading:12502874-B-Lymphocytes,
pubmed-meshheading:12502874-DNA, Viral,
pubmed-meshheading:12502874-Humans,
pubmed-meshheading:12502874-Mice,
pubmed-meshheading:12502874-Mice, SCID,
pubmed-meshheading:12502874-RNA, Messenger,
pubmed-meshheading:12502874-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:12502874-Simian virus 40
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pubmed:year |
2003
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pubmed:articleTitle |
Simian virus 40 sequences in human lymphoblastoid B-cell lines.
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pubmed:affiliation |
Divisions of Experimental Oncology, Centro di Riferimento Oncologico, IRCCS, 33081 Aviano (Pordenone), Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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