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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2002-12-25
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pubmed:abstractText |
Protease inhibitors (PIs) are substrates for the P-glycoprotein (P-gp/170) encoded by the multi-drug resistance gene (MDR-1). HIV infection is associated with increased expression of P-gp. The role of MDR gene overexpression in clinical pharmacokinetics is not known.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Carbamates,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers,
http://linkedlifedata.com/resource/pubmed/chemical/HIV Protease Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Indinavir,
http://linkedlifedata.com/resource/pubmed/chemical/Nelfinavir,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Ritonavir,
http://linkedlifedata.com/resource/pubmed/chemical/Saquinavir,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfonamides,
http://linkedlifedata.com/resource/pubmed/chemical/amprenavir
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pubmed:status |
MEDLINE
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pubmed:issn |
1528-4336
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
3
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
493-501
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pubmed:dateRevised |
2006-11-30
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pubmed:meshHeading |
pubmed-meshheading:12501133-Adult,
pubmed-meshheading:12501133-Antiretroviral Therapy, Highly Active,
pubmed-meshheading:12501133-Carbamates,
pubmed-meshheading:12501133-DNA Primers,
pubmed-meshheading:12501133-Drug Administration Schedule,
pubmed-meshheading:12501133-Female,
pubmed-meshheading:12501133-Gene Expression Regulation,
pubmed-meshheading:12501133-Genes, MDR,
pubmed-meshheading:12501133-HIV Infections,
pubmed-meshheading:12501133-HIV Protease Inhibitors,
pubmed-meshheading:12501133-HIV-1,
pubmed-meshheading:12501133-Humans,
pubmed-meshheading:12501133-Indinavir,
pubmed-meshheading:12501133-Leukocytes, Mononuclear,
pubmed-meshheading:12501133-Male,
pubmed-meshheading:12501133-Nelfinavir,
pubmed-meshheading:12501133-Pilot Projects,
pubmed-meshheading:12501133-RNA, Messenger,
pubmed-meshheading:12501133-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:12501133-Ritonavir,
pubmed-meshheading:12501133-Saquinavir,
pubmed-meshheading:12501133-Sulfonamides,
pubmed-meshheading:12501133-Viral Load
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pubmed:articleTitle |
Intracellular concentration of protease inhibitors in HIV-1-infected patients: correlation with MDR-1 gene expression and low dose of ritonavir.
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pubmed:affiliation |
Service des Maladies Infectieuses, Hôpital Archet 1, Nice, France. chaillou.s@chu-nice.fr
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pubmed:publicationType |
Journal Article
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