Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2002-12-24
pubmed:abstractText
In a previous functional magnetic resonance imaging (fMRI) study with normal subjects, we demonstrated regions related to conceptual-semantic word processing around the first frontal sulcus (BA 9) and the posterior parietal lobe (BA 7/40) in agreement with several previous reports. We had the possibility, using the same fMRI paradigm, to study two consecutive cases with left middle cerebral artery (MCA) infarction (RC and HP) and lesions affecting either solely the pre-frontal (HP) or both the pre-frontal and posterior parietal part of the network activated in normal subjects (RC). Both patients showed transcortical sensory aphasia (TSA) on acute assessment. This contradicts classical disconnection accounts of the syndrome stating intact conceptual representations in TSA. Their recovery of language comprehension was associated with activation of a left hemispheric network. Mainly activations of left perilesional pre-frontal regions (RC), left Wernicke's area (RC and HP) or the left posterior middle and inferior temporal cortex (HP) were demonstrated in the TSA patients. The latter findings suggest that in our cases of TSA functional take-over has occurred in regions with related functions ('redundancy recovery') rather than in previously unrelated areas ('vicarious functioning'). Our data support distributed models of conceptual-semantic word processing and multiple left hemispheric representations of closely related functions.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
1355-4794
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
376-86
pubmed:dateRevised
2011-3-1
pubmed:meshHeading
pubmed-meshheading:12499412-Adult, pubmed-meshheading:12499412-Aged, pubmed-meshheading:12499412-Aphasia, Wernicke, pubmed-meshheading:12499412-Brain Mapping, pubmed-meshheading:12499412-Cerebral Cortex, pubmed-meshheading:12499412-Dominance, Cerebral, pubmed-meshheading:12499412-Follow-Up Studies, pubmed-meshheading:12499412-Humans, pubmed-meshheading:12499412-Infarction, Middle Cerebral Artery, pubmed-meshheading:12499412-Magnetic Resonance Imaging, pubmed-meshheading:12499412-Male, pubmed-meshheading:12499412-Middle Aged, pubmed-meshheading:12499412-Nerve Net, pubmed-meshheading:12499412-Neuronal Plasticity, pubmed-meshheading:12499412-Neuropsychological Tests, pubmed-meshheading:12499412-Reading, pubmed-meshheading:12499412-Reference Values, pubmed-meshheading:12499412-Semantics, pubmed-meshheading:12499412-Speech Perception
pubmed:year
2002
pubmed:articleTitle
Recovery of semantic word processing in transcortical sensory aphasia: a functional magnetic resonance imaging study.
pubmed:affiliation
Department of Neurology, Neurolinguistics Section, University of Technology, RWTH Aachen, Germany. roland_zahn@psyallg.ukl-freiburg.de
pubmed:publicationType
Journal Article, Case Reports, Research Support, Non-U.S. Gov't