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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2003-1-1
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pubmed:abstractText |
Human mitochondrial transcription factor B1 (h-mtTFB1) has an unprecedented relationship to RNA methyltransferases. Here, we show that this protein methylates a conserved stem-loop in bacterial 16S rRNA and that the homologous sequence in the human mitochondrial 12S molecule is similarly modified. Thus, h-mtTFB1 appears to be dual-function protein, acting both as a transcription factor and an rRNA-modification enzyme.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Aminoglycosides,
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Bacterial Agents,
http://linkedlifedata.com/resource/pubmed/chemical/B1 factor, Xenopus,
http://linkedlifedata.com/resource/pubmed/chemical/Methyltransferases,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Bacterial,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Ribosomal,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Ribosomal, 16S,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, ribosomal, 12S,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Upstream Stimulatory Factors,
http://linkedlifedata.com/resource/pubmed/chemical/kasugamycin,
http://linkedlifedata.com/resource/pubmed/chemical/ksgA methyltransferase
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1061-4036
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
33
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
23-4
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12496758-Aminoglycosides,
pubmed-meshheading:12496758-Anti-Bacterial Agents,
pubmed-meshheading:12496758-Base Sequence,
pubmed-meshheading:12496758-Conserved Sequence,
pubmed-meshheading:12496758-Escherichia coli,
pubmed-meshheading:12496758-Gene Deletion,
pubmed-meshheading:12496758-Humans,
pubmed-meshheading:12496758-Methylation,
pubmed-meshheading:12496758-Methyltransferases,
pubmed-meshheading:12496758-Mitochondria,
pubmed-meshheading:12496758-Nucleic Acid Conformation,
pubmed-meshheading:12496758-RNA, Bacterial,
pubmed-meshheading:12496758-RNA, Ribosomal,
pubmed-meshheading:12496758-RNA, Ribosomal, 16S,
pubmed-meshheading:12496758-Transcription Factors,
pubmed-meshheading:12496758-Upstream Stimulatory Factors
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pubmed:year |
2003
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pubmed:articleTitle |
Human mitochondrial transcription factor B1 methylates ribosomal RNA at a conserved stem-loop.
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pubmed:affiliation |
Department of Biochemistry, Rollins Research Center, Emory University School of Medicine, Atlanta, Georgia 30322-3050, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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