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| pubmed-article:12490613 | lifeskim:mentions | umls-concept:C0033634 | lld:lifeskim |
| pubmed-article:12490613 | lifeskim:mentions | umls-concept:C0030685 | lld:lifeskim |
| pubmed-article:12490613 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:12490613 | lifeskim:mentions | umls-concept:C0680255 | lld:lifeskim |
| pubmed-article:12490613 | lifeskim:mentions | umls-concept:C0391871 | lld:lifeskim |
| pubmed-article:12490613 | lifeskim:mentions | umls-concept:C1283071 | lld:lifeskim |
| pubmed-article:12490613 | lifeskim:mentions | umls-concept:C1963578 | lld:lifeskim |
| pubmed-article:12490613 | lifeskim:mentions | umls-concept:C0851827 | lld:lifeskim |
| pubmed-article:12490613 | lifeskim:mentions | umls-concept:C1701901 | lld:lifeskim |
| pubmed-article:12490613 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:12490613 | pubmed:dateCreated | 2002-12-19 | lld:pubmed |
| pubmed-article:12490613 | pubmed:abstractText | We have previously shown that sigma1 receptor agonists inhibit N-methyl-D-aspartate (NMDA)-stimulated [3H]dopamine from slices of rat striatum in a concentration-related manner and that the inhibition is reversed by sigma1 receptor-selective and nonsubtype-selective sigma receptor antagonists. Based on previous evidence from our laboratory as well as other laboratories, we hypothesized that sigma1 receptors might use a protein kinase C (PKC) signaling pathway to modulate stimulated dopamine release. We tested several inhibitors of PKC isozymes, as well as a phospholipase C inhibitor for their effects on sigma1 receptor agonist-mediated regulation of [3H]dopamine release. Although none of the inhibitors tested affected the ability of NMDA to stimulate [3H]dopamine release, they all abolished regulation by the sigma1 receptor agonist (+)-pentazocine in a concentration-related manner. We also found that prior exposure to 1 microM phorbol 2-myristate 13-acetate for 30 min abolished regulation by (+)-pentazocine. We concluded that an intact PKC system was required for sigma1 agonist-mediated regulation of NMDA-stimulated [3H]dopamine release from rat striatal slices. Based on the pharmacological profile of the PKC inhibitors tested, as well as reports in the literature on PKC | lld:pubmed |
| pubmed-article:12490613 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12490613 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12490613 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12490613 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12490613 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:12490613 | pubmed:issn | 0022-3565 | lld:pubmed |
| pubmed-article:12490613 | pubmed:author | pubmed-author:WerlingLinda... | lld:pubmed |
| pubmed-article:12490613 | pubmed:author | pubmed-author:NuwayhidSamer... | lld:pubmed |
| pubmed-article:12490613 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12490613 | pubmed:volume | 304 | lld:pubmed |
| pubmed-article:12490613 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12490613 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12490613 | pubmed:pagination | 364-9 | lld:pubmed |
| pubmed-article:12490613 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:12490613 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12490613 | pubmed:articleTitle | Sigma1 receptor agonist-mediated regulation of N-methyl-D-aspartate-stimulated [3H]dopamine release is dependent upon protein kinase C. | lld:pubmed |
| pubmed-article:12490613 | pubmed:affiliation | Department of Pharmacology, The George Washington University Medical Center, Washington, DC 20037, USA. | lld:pubmed |
| pubmed-article:12490613 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12490613 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:12490613 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12490613 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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