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pubmed-article:12487389pubmed:abstractTextStavudine-based antiretroviral combinations are less effective in zidovudine-experienced patients than in naive subjects and recently, mutations have been described to be associated to the use of both stavudine and zidovudine. In the ALTIS 2 trial, it was shown that a combination of stavudine and lamivudine is less effective in zidovudine-experienced patients than in naive patients. We conducted a retrospective genotypic and phenotypic resistance study (expressed as stavudine phenotypic index, calculated by dividing the inhibitory concentrations 50% [IC50] by the mean value of the sensitive viruses) to evaluate the factors associated with decrease in plasma HIV-1 RNA.lld:pubmed
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pubmed-article:12487389pubmed:affiliationDepartment of Virology and Infectious Diseases and Pitie-Salpetrière Hospital, Paris, France. vincent.calvez@psl.ap-hop-paris.frlld:pubmed
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