|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0166415,
umls-concept:C0205174,
umls-concept:C0205309,
umls-concept:C0205314,
umls-concept:C0220781,
umls-concept:C0439097,
umls-concept:C0678594,
umls-concept:C0679622,
umls-concept:C1547348,
umls-concept:C1552644,
umls-concept:C1554184,
umls-concept:C1705241,
umls-concept:C1705542,
umls-concept:C1707689,
umls-concept:C1823153,
umls-concept:C1883254,
umls-concept:C2349976
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2002-12-16
|
|
pubmed:abstractText |
Using a known dual PPARalpha/gamma activator (5) as a structural template, SAR evaluations led to the identification of triple PPARalpha/gamma/delta activators (18-20) with equal potency and efficacy on all three receptors. These compounds could become useful tools for studying the combined biological effects of PPARalpha/gamma/delta activation.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
|
pubmed:issn |
0960-894X
|
|
pubmed:author |
pubmed-author:AlbrektsenTatjanaT,
pubmed-author:BuryPaul SPS,
pubmed-author:DinNanniN,
pubmed-author:FlecknerJanJ,
pubmed-author:FrederiksenKlaus SKS,
pubmed-author:JeppesenLoneL,
pubmed-author:MogensenJohn PJP,
pubmed-author:MortensenSteen BSB,
pubmed-author:NehlinJanJ,
pubmed-author:PetterssonIngridI,
pubmed-author:SauerbergPerP,
pubmed-author:SvenssonL AndersLA,
pubmed-author:WassermannKarstenK,
pubmed-author:WulffErik MEM,
pubmed-author:YnddalLarsL
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
20
|
|
pubmed:volume |
13
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
257-60
|
|
pubmed:dateRevised |
2011-11-17
|
|
pubmed:meshHeading |
pubmed-meshheading:12482434-Animals,
pubmed-meshheading:12482434-Blood Glucose,
pubmed-meshheading:12482434-Glucose Tolerance Test,
pubmed-meshheading:12482434-Insulin,
pubmed-meshheading:12482434-Male,
pubmed-meshheading:12482434-Mice,
pubmed-meshheading:12482434-Models, Molecular,
pubmed-meshheading:12482434-Molecular Conformation,
pubmed-meshheading:12482434-Receptors, Cytoplasmic and Nuclear,
pubmed-meshheading:12482434-Structure-Activity Relationship,
pubmed-meshheading:12482434-Transcription Factors
|
|
pubmed:year |
2003
|
|
pubmed:articleTitle |
Design and synthesis of novel PPARalpha/gamma/delta triple activators using a known PPARalpha/gamma dual activator as structural template.
|
|
pubmed:affiliation |
Novo Nordisk A/S, Novo Nordisk Park, 2760 Måløv, Denmark. jpm@novonordisk.com
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
