Source:http://linkedlifedata.com/resource/pubmed/id/12480179
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1-2
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pubmed:dateCreated |
2002-12-13
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pubmed:abstractText |
In order to evaluate the role of transforming growth factor (TGF)-beta3 in the neurodegenerative process, we examined the levels of mRNA and immunocytochemical distribution for TGF-beta3 in the rat hippocampus after systemic kainic acid (KA) administration. Hippocampal TGF-beta3 mRNA level was reduced 3 h after KA injection. However, the levels of TGF-beta3 mRNA were elevated 1 day post-KA and lasted for at least 30 days. A mild TGF-beta3 immunoreactivity (TGF-beta3-IR) in the Ammon's horn and a moderate TGF-beta3-IR in the dentate granule cells were observed in the normal hippocampus. The CA1 and CA3 neurons lost their TGF-beta3-IR, while TGF-beta3-positive glia-like cells proliferated mainly throughout the CA1 sector and had an intense immunoreactivity at 7, 15 and 30 days after KA. This immunocytochemical distribution of TGF-beta3-positive non-neuronal populations was similar to that of glial fibrillary acidic protein (GFAP)-positive cells. Double labeling immunocytochemical analysis demonstrated colocalization of TGF-beta3- and GFAP-immunoreactivity in the same cells. These findings suggest a compensatory mechanism of astrocytes for the synthesis of TGF-beta3 protein in response to KA-induced neurodegeneration. In addition, exogenous TGF-beta3 (5 or 10 ng/i.c.v.) significantly attenuated KA-induced seizures and neuronal damages in a dose-related manner. Therefore, our results suggest that TGF-beta3 plays an important role in protective mechanisms against KA-induced neurodegeneration.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Excitatory Amino Acid Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Glial Fibrillary Acidic Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Kainic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Neuroprotective Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Tgfb3 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta3
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0169-328X
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pubmed:author |
pubmed-author:BingGuoyingG,
pubmed-author:Bok WieMyungM,
pubmed-author:ChoiShin-GeonSG,
pubmed-author:FlandersKathleen CKC,
pubmed-author:HongJau-ShyongJS,
pubmed-author:JhooWang-KeeWK,
pubmed-author:KimHyoung-ChunHC,
pubmed-author:KimSeong-JinSJ,
pubmed-author:KimWon-KiWK,
pubmed-author:KoKwang HoKH,
pubmed-author:ShinEun-JooEJ
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pubmed:issnType |
Print
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pubmed:volume |
108
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
60-70
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12480179-Animals,
pubmed-meshheading:12480179-Behavior, Animal,
pubmed-meshheading:12480179-Cell Size,
pubmed-meshheading:12480179-Excitatory Amino Acid Agonists,
pubmed-meshheading:12480179-Glial Fibrillary Acidic Protein,
pubmed-meshheading:12480179-Hippocampus,
pubmed-meshheading:12480179-Immunohistochemistry,
pubmed-meshheading:12480179-Kainic Acid,
pubmed-meshheading:12480179-Male,
pubmed-meshheading:12480179-Neuroglia,
pubmed-meshheading:12480179-Neuroprotective Agents,
pubmed-meshheading:12480179-Rats,
pubmed-meshheading:12480179-Rats, Inbred F344,
pubmed-meshheading:12480179-Seizures,
pubmed-meshheading:12480179-Transforming Growth Factor beta,
pubmed-meshheading:12480179-Transforming Growth Factor beta3
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pubmed:year |
2002
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pubmed:articleTitle |
Kainate treatment alters TGF-beta3 gene expression in the rat hippocampus.
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pubmed:affiliation |
Neurotoxicology Program, College of Pharmacy, Korea Institute of Drug Abuse, Kangwon National University, Chunchon 200-701, South Korea. kimhc@cc.kangwon.ac.kr
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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