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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2002-12-12
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pubmed:abstractText |
Peroxynitrite is a cytotoxic oxidant formed from nitric oxide (NO) and superoxide. Tyrosine nitration, a footprint of peroxynitrite, has been demonstrated in the pancreatic islets as well as in the cardiovascular system of diabetic subjects. Delineation of the pathogenetic role of peroxynitrite in disease conditions requires the use of potent, in vivo active peroxynitrite decomposition catalysts. The aim of the current work was to produce a potent peroxynitrite decomposition catalyst and to test its effects in rodent models of diabetes and its complications.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1076-1551
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pubmed:author |
pubmed-author:GrovesJohn TJT,
pubmed-author:MableyJon GJG,
pubmed-author:MoellerSuzanne MSM,
pubmed-author:PacherPálP,
pubmed-author:SalzmanAndrew LAL,
pubmed-author:ShimanovichRomanR,
pubmed-author:SorianoFrancisco GFG,
pubmed-author:SzabóCsabaC,
pubmed-author:Van DuzerJohn HJH,
pubmed-author:ViragLászlóL,
pubmed-author:WilliamsWilliamW
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pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
571-80
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pubmed:dateRevised |
2008-11-20
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pubmed:meshHeading |
pubmed-meshheading:12477967-Animals,
pubmed-meshheading:12477967-Catalysis,
pubmed-meshheading:12477967-Cytoprotection,
pubmed-meshheading:12477967-Diabetes Mellitus, Experimental,
pubmed-meshheading:12477967-Disease Models, Animal,
pubmed-meshheading:12477967-Dose-Response Relationship, Drug,
pubmed-meshheading:12477967-Female,
pubmed-meshheading:12477967-Islets of Langerhans,
pubmed-meshheading:12477967-Kinetics,
pubmed-meshheading:12477967-Male,
pubmed-meshheading:12477967-Metalloporphyrins,
pubmed-meshheading:12477967-Mice,
pubmed-meshheading:12477967-Mice, Inbred BALB C,
pubmed-meshheading:12477967-Nitrates,
pubmed-meshheading:12477967-Peroxynitrous Acid,
pubmed-meshheading:12477967-Phenol,
pubmed-meshheading:12477967-Vascular Diseases
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pubmed:year |
2002
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pubmed:articleTitle |
Part I: pathogenetic role of peroxynitrite in the development of diabetes and diabetic vascular complications: studies with FP15, a novel potent peroxynitrite decomposition catalyst.
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pubmed:affiliation |
Inotek Pharmaceuticals Corporation, Beverly, Massachusetts, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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