Linked Life Data

12477255

Source:http://linkedlifedata.com/resource/pubmed/id/12477255

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2002-12-12
pubmed:abstractText
For more than two decades, there has been a concerted effort to define the biology of, and develop the clinical applications for, cytokines that influence the immune system. However, intrinsic potency and toxicity have complicated application of cytokines as therapeutic agents when applied systemically. Indeed, one of the major characteristics of most cytokines is that they regulate immunity at a local or regional level, and systemic levels provided by most conventional schema fail to mimic the induction of an effective immune response. IL-4 has pleiotropic effects on immune cells of multiple lineages, endothelial cells and tumor cells. Accumulating data in pre-clinical studies demonstrate that sustained expression of IL-4 at the targeted organs or tissues may provide an effective means for therapy of variety of diseases including cancers and immunologic disorders. This review discusses biological properties and therapeutic applications of IL-4, particularly when it is delivered as a transgene in the settings of gene therapy.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1566-5232
pubmed:author
pubmed:issnType
Print
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
437-50
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Gene therapy and biologic therapy with interleukin-4.
pubmed:affiliation
University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213-1863 , USA. okadah@msx.upmc.edu
pubmed:publicationType
Journal Article, Review