Linked Life Data

1247599

Source:http://linkedlifedata.com/resource/pubmed/id/1247599

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1976-4-30
pubmed:abstractText
Thymidylate synthetase (EC 2.1.1) from in vitro 3-methylcholanthreneor Rauscher leukemia virus-transformed rat embryo cells was studied. The enzyme from control or transformed rat cells exhibited a Km for 2'-deoxyuridylic acid of 4.5 +/- 0.2 muM, but the transformants had a higher level of enzyme activity than did control cells. Titration of the enzyme with tritiated 5-fluoro2'-deoxyuridylic acid indicated that the increased enzyme activity in the transformants was due to a greater level of cellular enzyme. While the level of enzyme activity in control cells was dependent on both the availability of nutrients in the medium and cell density, the level of enzyme activity in the transformants appeared to depend only on the availability of nutrients.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0006-3002
pubmed:author
pubmed:issnType
Print
pubmed:day
13
pubmed:volume
422
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
295-301
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1976
pubmed:articleTitle
Thymidylate synthetase of in vitro chemically and virally transformed rat cells.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.