Source:http://linkedlifedata.com/resource/pubmed/id/12472598
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
2002-12-10
|
| pubmed:abstractText |
Certain cytokine gene polymorphisms may be associated with severe acute graft-versus-host disease (GVHD) after allogeneic stem cell transplantation. The present study analysed 196 patients and their donors for TNF-308, TNFd, IL-10-1064 and IL-10-1082 gene polymorphisms. Serum analysis of tumour necrosis factor-alpha (TNF-alpha) and interleukin 10 (IL-10) levels during conditioning therapy was also performed. Among patients with sibling donors, the TNFd allele 4 was significantly correlated with acute GVHD grades II-IV (P < 0.01). Acute GVHD grades II-IV were more common among patients homozygous for the IL-10-1064 allele 13 (P = 0.02). Patients homozygous for the TNF-308 allele (AA) correlated with higher TNF-alpha serum levels during conditioning (P = 0.02).
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0007-1048
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
119
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1133-6
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:12472598-Acute Disease,
pubmed-meshheading:12472598-Adolescent,
pubmed-meshheading:12472598-Adult,
pubmed-meshheading:12472598-Alleles,
pubmed-meshheading:12472598-Child,
pubmed-meshheading:12472598-Child, Preschool,
pubmed-meshheading:12472598-Female,
pubmed-meshheading:12472598-Gene Frequency,
pubmed-meshheading:12472598-Genetic Predisposition to Disease,
pubmed-meshheading:12472598-Graft vs Host Disease,
pubmed-meshheading:12472598-Hematologic Neoplasms,
pubmed-meshheading:12472598-Hematopoietic Stem Cell Transplantation,
pubmed-meshheading:12472598-Humans,
pubmed-meshheading:12472598-Infant,
pubmed-meshheading:12472598-Infant, Newborn,
pubmed-meshheading:12472598-Interleukin-10,
pubmed-meshheading:12472598-Male,
pubmed-meshheading:12472598-Middle Aged,
pubmed-meshheading:12472598-Polymorphism, Genetic,
pubmed-meshheading:12472598-Transplantation Conditioning,
pubmed-meshheading:12472598-Tumor Necrosis Factor-alpha
|
| pubmed:year |
2002
|
| pubmed:articleTitle |
The TNFd4 allele is correlated to moderate-to-severe acute graft-versus-host disease after allogeneic stem cell transplantation.
|
| pubmed:affiliation |
Department of Clinical Immunology, and Centre for Allogeneic Stem Cell Transplantation, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|