12470891

Source:http://linkedlifedata.com/resource/pubmed/id/12470891

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0013139, umls-concept:C0017337, umls-concept:C0023980, umls-concept:C0680730, umls-concept:C1148554
pubmed:issue	12
pubmed:dateCreated	2002-12-9
pubmed:abstractText	Identification of longevity mutants is crucial for genetic approach to dissect the molecular mechanism of aging and longevity determination. In Drosophila melanogaster, several mutations have been shown to extend the longevity: methuselah encoding a putative G-protein coupled receptor, Indy encoding a sodium dicarboxylate cotransporter, chico encoding insulin receptor substrate, and InR encoding the insulin-like receptor. Extended longevity phenotypes were also observed in transgenic flies overexpressing antioxidant enzymes, Cu/Zn superoxide dismutase and Catalase, Cu/Zn SOD only, or a molecular chaperone, hsp70. Pleiotropism of mutations is a limitation associated with conventional mutagenesis for efficient detection of longevity determination genes. Using a conditional misexpression system, we identified Drosophila POSH (DPOSH), a scaffold protein containing RING finger and four SH3 domains, whose ubiquitous overexpression in adult stage extends the longevity. Neural-specific overexpression of DPOSH is sufficient to extend the longevity, whereas overexpression in non-neural tissues during development induces apoptosis through activation of JNK/SAPK pathway.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0347227
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	Nov
pubmed:issn	0047-6374
pubmed:author	pubmed-author:AigakiToshiroT, pubmed-author:MatsuoTakashiT, pubmed-author:SeongKi-hyeonKH
pubmed:copyrightInfo	Copyright 2002 Publidhed by Elsevier Science Ireland Ltd.
pubmed:issnType	Print
pubmed:volume	123
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	1531-41
pubmed:dateRevised	2006-11-15
pubmed:meshHeading	pubmed-meshheading:12470891-Animals, pubmed-meshheading:12470891-Drosophila melanogaster, pubmed-meshheading:12470891-Longevity
pubmed:year	2002
pubmed:articleTitle	Longevity determination genes in Drosophila melanogaster.
pubmed:affiliation	Department of Biological Sciences, Tokyo Metropolitan University, 1-1 Minami-osawa, Hachioji-shi, Tokyo 192-0397, Japan. aigaki-toshiro@c.metro-u.ac.jp
pubmed:publicationType	Journal Article, Review, Research Support, Non-U.S. Gov't