|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
2002-12-4
|
|
pubmed:abstractText |
Understanding the cell type-specific molecular mechanisms by which distinct signaling pathways combinatorially control proliferation during organogenesis is a central issue in development and disease. Here, we report that the bicoid-related transcription factor Pitx2 is rapidly induced by the Wnt/Dvl/beta-catenin pathway and is required for effective cell-type-specific proliferation by directly activating specific growth-regulating genes. Regulated exchange of HDAC1/beta-catenin converts Pitx2 from repressor to activator, analogous to control of TCF/LEF1. Pitx2 then serves as a competence factor required for the temporally ordered and growth factor-dependent recruitment of a series of specific coactivator complexes that prove necessary for Cyclin D2 gene induction. The molecular strategy underlying interactions between the Wnt and growth factor-dependent signaling pathways in cardiac outflow tract and pituitary proliferation is likely to be prototypic of cell-specific proliferation strategies in other tissues.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/Catnb protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Ccnd2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin D2,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclins,
http://linkedlifedata.com/resource/pubmed/chemical/Cytoskeletal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Histone Deacetylases,
http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Wnt Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Zebrafish Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/beta Catenin,
http://linkedlifedata.com/resource/pubmed/chemical/dishevelled proteins,
http://linkedlifedata.com/resource/pubmed/chemical/homeobox protein PITX2
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
0092-8674
|
|
pubmed:author |
pubmed-author:BaekSung HeeSH,
pubmed-author:BraultVeroniqueV,
pubmed-author:BriataPaolaP,
pubmed-author:ChimonJ LJL,
pubmed-author:GlassChristopher KCK,
pubmed-author:GleibermanAnatoliA,
pubmed-author:HambletNatasha SNS,
pubmed-author:HermanThomasT,
pubmed-author:KemlerRolfR,
pubmed-author:KioussiChrissaC,
pubmed-author:NguyenH DHD,
pubmed-author:OhgiKenneth AKA,
pubmed-author:RoseDavid WDW,
pubmed-author:RosenfeldMichael GMG,
pubmed-author:Ruiz-LozanoPilarP,
pubmed-author:WangJianboJ,
pubmed-author:Wynshaw-BorisAnthonyA
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
27
|
|
pubmed:volume |
111
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
673-85
|
|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:12464179-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:12464179-Animals,
pubmed-meshheading:12464179-Cell Division,
pubmed-meshheading:12464179-Cell Line,
pubmed-meshheading:12464179-Cyclin D2,
pubmed-meshheading:12464179-Cyclins,
pubmed-meshheading:12464179-Cytoskeletal Proteins,
pubmed-meshheading:12464179-Gene Expression Regulation, Developmental,
pubmed-meshheading:12464179-Heart,
pubmed-meshheading:12464179-Histone Deacetylases,
pubmed-meshheading:12464179-Homeodomain Proteins,
pubmed-meshheading:12464179-Mice,
pubmed-meshheading:12464179-Mice, Knockout,
pubmed-meshheading:12464179-Mice, Transgenic,
pubmed-meshheading:12464179-Models, Biological,
pubmed-meshheading:12464179-Nuclear Proteins,
pubmed-meshheading:12464179-Organogenesis,
pubmed-meshheading:12464179-Phosphoproteins,
pubmed-meshheading:12464179-Pituitary Gland,
pubmed-meshheading:12464179-Proteins,
pubmed-meshheading:12464179-Proto-Oncogene Proteins,
pubmed-meshheading:12464179-Signal Transduction,
pubmed-meshheading:12464179-Trans-Activators,
pubmed-meshheading:12464179-Transcription Factors,
pubmed-meshheading:12464179-Transcriptional Activation,
pubmed-meshheading:12464179-Wnt Proteins,
pubmed-meshheading:12464179-Zebrafish Proteins,
pubmed-meshheading:12464179-beta Catenin
|
|
pubmed:year |
2002
|
|
pubmed:articleTitle |
Identification of a Wnt/Dvl/beta-Catenin --> Pitx2 pathway mediating cell-type-specific proliferation during development.
|
|
pubmed:affiliation |
Howard Hughes Medical Institute, University of California, San Diego, School of Medicine, CMM-West, Room 345, 9500 Gilman Drive, La Jolla, CA 92093, USA.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
