Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2002-12-4
pubmed:abstractText
This study examined whether alterations of the spontaneous and evoked mechanical activity are present in the stomach of the mdx mouse, the animal model for Duchenne muscular dystrophy. The gastric mechanical activity from whole-organ of normal and mdx mice was recorded in vitro as changes of intraluminal pressure. All gastric preparations developed spontaneous tone and phasic contractions, although the tone of the mdx preparations was significantly greater. Atropine reduced the tone of the two preparations by the same degree. Nomega-nitro-l-arginine methyl ester (l-NAME) significantly increased the tone and spontaneous contractions only in the stomach from normal animals, but did not affect on the mdx preparations. Effects ofl-NAME on tone and contractility were preserved in the presence of tetrodotoxin. In both types of tissues electrical field stimulation (EFS) induced a biphasic response: cholinergic contraction followed by slow relaxation. In nonadrenergic noncholinergic conditions, EFS induced a rapid relaxation followed by a slow component in both types of tissues. l-NAME abolished the rapid component, reduced the slow component and unmasked tachychinergic contractions. No significant difference was found in evoked responses. The enteric neurotransmission is preserved in mdx gastric preparations, although alterations in the ongoing production of nitric oxide are present.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1350-1925
pubmed:author
pubmed:issnType
Print
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
667-75
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:12464089-Anesthetics, Local, pubmed-meshheading:12464089-Animals, pubmed-meshheading:12464089-Carbachol, pubmed-meshheading:12464089-Cholinergic Agonists, pubmed-meshheading:12464089-Electric Stimulation, pubmed-meshheading:12464089-Enzyme Inhibitors, pubmed-meshheading:12464089-Male, pubmed-meshheading:12464089-Mice, pubmed-meshheading:12464089-Mice, Inbred mdx, pubmed-meshheading:12464089-Muscle, Smooth, pubmed-meshheading:12464089-Muscle Contraction, pubmed-meshheading:12464089-Muscular Dystrophy, Animal, pubmed-meshheading:12464089-Muscular Dystrophy, Duchenne, pubmed-meshheading:12464089-NG-Nitroarginine Methyl Ester, pubmed-meshheading:12464089-Nitric Oxide, pubmed-meshheading:12464089-Nitric Oxide Donors, pubmed-meshheading:12464089-Nitroprusside, pubmed-meshheading:12464089-Organ Culture Techniques, pubmed-meshheading:12464089-Stomach, pubmed-meshheading:12464089-Tetrodotoxin
pubmed:year
2002
pubmed:articleTitle
Spontaneous mechanical activity and evoked responses in isolated gastric preparations from normal and dystrophic (mdx) mice.
pubmed:affiliation
Dipartimento di Biologia cellulare e dello Sviluppo, Università di Palermo, Italia. fmule@unipa.it
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't