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pubmed:abstractText |
The p53 oncosuppressor protein is a critical mediator of the response to injury in mammalian cells and is mutationally inactivated in the majority of lung malignancies. In this analysis, the effects of p53-deficiency were investigated in short-term primary cultures of murine bronchiolar Clara cells. Clara cells, isolated from gene-targeted p53-deficient mice, were compared to cells derived from wild type littermates.
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pubmed:affiliation |
CRC Laboratories, Department of Pathology, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK. chrisa@hgu.mrc.ac.uk
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