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rdf:type |
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lifeskim:mentions |
umls-concept:C0004083,
umls-concept:C0030705,
umls-concept:C0085228,
umls-concept:C0086860,
umls-concept:C0289174,
umls-concept:C0871261,
umls-concept:C1269683,
umls-concept:C1335671,
umls-concept:C1556094,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C1882417,
umls-concept:C2911692
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pubmed:issue |
3
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pubmed:dateCreated |
2002-11-7
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pubmed:abstractText |
Genetic polymorphism of the serotonin 5-HT(2A) receptor seems to be associated with therapeutic response to selective serotonin reuptake inhibitors (SSRIs). The present study investigated whether a novel -1438G/A polymorphism in the promoter region of the 5-HT(2A )receptor gene is associated with therapeutic response to fluvoxamine (an SSRI) in 66 Japanese patients with major depressive disorder. Fluvoxamine (50 to 200 mg) was administered twice daily for 6 weeks. Fifty-four patients completed this study. The genotype distribution and the allele frequencies showed no significant difference between responders and non-responders. The time-course of the Montgomery-Asberg Depression Rating Scale scores showed no significant difference among -1438G/G, -1438G/A, and -1438A/A genotype groups. The results demonstrated that the -1438G/A promoter polymorphism in the 5-HT(2A) receptor gene was unlikely to have a major role in therapeutic response to fluvoxamine in Japanese patients with major depressive disorder.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0302-282X
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pubmed:author |
pubmed-author:HiguchiHisashiH,
pubmed-author:InoueKazuyukiK,
pubmed-author:ItoKenichiK,
pubmed-author:ItohKunihikoK,
pubmed-author:KamataMitsuhiroM,
pubmed-author:OhkuboTaashiT,
pubmed-author:OtaniKoichiK,
pubmed-author:SatoKazuhiroK,
pubmed-author:ShimizuTetsuoT,
pubmed-author:SugawaraKazunobuK,
pubmed-author:SuzukiToshioT,
pubmed-author:TakahashiHitoshiH,
pubmed-author:TezukaTakehikoT,
pubmed-author:YoshidaKeizoK
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pubmed:copyrightInfo |
Copyright 2002 S. Karger AG, Basel
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pubmed:issnType |
Print
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pubmed:volume |
46
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
136-40
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:12422060-Adult,
pubmed-meshheading:12422060-Aged,
pubmed-meshheading:12422060-Chi-Square Distribution,
pubmed-meshheading:12422060-Depressive Disorder, Major,
pubmed-meshheading:12422060-Dose-Response Relationship, Drug,
pubmed-meshheading:12422060-Female,
pubmed-meshheading:12422060-Fluvoxamine,
pubmed-meshheading:12422060-Gene Frequency,
pubmed-meshheading:12422060-Genotype,
pubmed-meshheading:12422060-Humans,
pubmed-meshheading:12422060-Japan,
pubmed-meshheading:12422060-Male,
pubmed-meshheading:12422060-Middle Aged,
pubmed-meshheading:12422060-Polymorphism, Single Nucleotide,
pubmed-meshheading:12422060-Promoter Regions, Genetic,
pubmed-meshheading:12422060-Psychiatric Status Rating Scales,
pubmed-meshheading:12422060-Receptor, Serotonin, 5-HT2A,
pubmed-meshheading:12422060-Receptors, Serotonin,
pubmed-meshheading:12422060-Serotonin Uptake Inhibitors,
pubmed-meshheading:12422060-Time Factors,
pubmed-meshheading:12422060-Treatment Outcome
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pubmed:year |
2002
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pubmed:articleTitle |
Association between -1438G/A promoter polymorphism in the 5-HT(2A) receptor gene and fluvoxamine response in Japanese patients with major depressive disorder.
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pubmed:affiliation |
Department of Psychiatry, Akita University School of Medicine, Akita, Japan. ICD45422@nifty.com
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, Non-U.S. Gov't
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