Source:http://linkedlifedata.com/resource/pubmed/id/12419951
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
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| pubmed:dateCreated |
2002-11-6
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| pubmed:abstractText |
Sho-saiko-to extract, a Chinese herbal medicine, is widely used for treatment of chronic hepatitis in Japan. However, it is not clear what conditions Sho-saiko-to extract improves hepatic inflammation and fibrosis. We therefore induced various stages of liver injury in model rats and administered Sho-saiko-to extract. We then evaluated the liver inflammation and liver fibrosis-improving effects of Sho-saiko-to extract. The liver injury model rats were produced by administration of various doses of dimethylnitrosamine (DMN) and Sho-saiko-to extract was administered to these rats. Then the liver inflammation and fibrosis-improving effects of Sho-saiko-to extract were evaluated according to L-asparate aminotransferase (AST), L-alanine aminotransferase (ALT), liver retinoid levels, levels of hydroxyproline, Transforming Growth Factor-beta (TGF-beta), and the liver fibrosis area. These indicators depended on the total doses of DMN. The ability of Sho-saiko-to extract to improve liver inflammation and fibrosis was limited to the following levels of the respective parameters: AST levels (234-264 U/l), ALT levels (208-232 U/l), TGF-beta levels (1102-1265 pg/g liver tissue), hydroxyproline levels (633-719 nmol/g liver tissue), and liver fibrosis area (9.7-10.6 times for normal rat). These findings suggested that Sho-saiko-to extract is effective in the treatment of liver inflammation and fibrosis up to a certain degree of severity, but it produces no improvement in more severe cases.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Nov
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| pubmed:issn |
0918-6158
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
25
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1417-21
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| pubmed:dateRevised |
2003-11-14
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| pubmed:meshHeading |
pubmed-meshheading:12419951-Animals,
pubmed-meshheading:12419951-Dimethylnitrosamine,
pubmed-meshheading:12419951-Dose-Response Relationship, Drug,
pubmed-meshheading:12419951-Drugs, Chinese Herbal,
pubmed-meshheading:12419951-Inflammation,
pubmed-meshheading:12419951-Liver,
pubmed-meshheading:12419951-Liver Cirrhosis, Experimental,
pubmed-meshheading:12419951-Male,
pubmed-meshheading:12419951-Phytotherapy,
pubmed-meshheading:12419951-Rats,
pubmed-meshheading:12419951-Rats, Wistar
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| pubmed:year |
2002
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| pubmed:articleTitle |
Effect of Sho-saiko-to extract on hepatic inflammation and fibrosis in dimethylnitrosamine induced liver injury rats.
|
| pubmed:affiliation |
Department of Pharmacy, Kochi Medical School Hospital, Kochi, Japan. kusunosm@kochi-ms.ac.jp
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| pubmed:publicationType |
Journal Article
|