Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2002-11-5
pubmed:abstractText
To dissect the influence of CD21/CD35 and FcgammaRIIB in antigen retention and humoral memory, we used an adoptive transfer model in which antigen-primed B and T lymphocytes were given to sublethally irradiated wild-type mice or mice deficient in CD21/CD35 (Cr2(-/-)) or FcgammaRIIB receptors (FcgammaRIIB(-/-)). Cr2(-/-) chimeras showed impaired memory as characterized by a decrease in antibody titer, reduced frequency of antibody secreting cells, an absence of affinity maturation, and significantly reduced recall response. The impaired memory in Cr2(-/-) chimeras corresponded with the reduced frequency of antigen-specific memory B cells. Interestingly, FcgammaRIIB(-/-) chimeras showed a differential phenotype with impaired splenic but normal bone marrow responses. These data suggest that CD21/CD35 on stroma, including follicular dendritic cells, is critical to the maintenance of long-term B lymphocyte memory.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/12417629-10623822, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417629-10662793, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417629-10779753, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417629-10843680, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417629-10881171, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417629-10975825, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417629-10981970, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417629-11006011, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417629-11034213, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417629-11043777, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417629-11069289, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417629-11239450, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417629-1188323, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417629-14214095, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417629-1425924, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417629-1910686, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417629-2150759, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417629-2388695, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417629-3034767, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417629-307015, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417629-3263573, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417629-3350037, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417629-3487461, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417629-351064, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417629-4168368, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417629-4168369, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417629-4169440, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417629-5841041, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417629-6966317, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417629-7500008, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417629-8011279, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417629-8552190, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417629-8600537, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417629-8622941, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417629-8624815, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417629-8684487, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417629-8717518, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417629-8752901, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417629-9217150, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417629-9278297, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417629-9500791, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417629-9510159, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417629-9529153, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417629-9554848, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417629-9605124, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417629-9697836, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417629-9723780
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0022-1007
pubmed:author
pubmed:issnType
Print
pubmed:day
4
pubmed:volume
196
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1189-99
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
B lymphocyte memory: role of stromal cell complement and FcgammaRIIB receptors.
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