Linked Life Data

12414100

Source:http://linkedlifedata.com/resource/pubmed/id/12414100

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2002-11-4
pubmed:abstractText
Serotonin (5-HT) 1A receptors have been implicated in a variety of conditions including, depression, suicidal behavior, and aggression. Post-mortem brain studies and in vivo imaging studies report a variety of age and sex effects on brain 5-HT(1A) binding. Behavioral data from 5-HT(1A) specific pharmacological challenges suggest a role for 5-HT(1A) receptors in aggression. The goal of the present study was to determine age, sex, and severity of life-time aggression effects on 5-HT(1A) binding potential (BP) in vivo using positron emission tomography (PET) and the high affinity 5-HT(1A) antagonist, [carbonyl-C-11]WAY-100635 in 12 healthy females (ages 41.0+/-15.7 years) and 13 healthy males (ages 39.6+/-15.5 years). Regions of interest included the dorsal raphe, anterior cingulate cortex, cingulate body, hippocampus, amygdala, medial prefrontal cortex (PFC), and orbital PFC. No significant correlation between age and BP was detected in any brain region. MANOVA of the first three principle components demonstrated a significantly higher BP in females compared with males (P=0.0127). Post-hoc tests confirmed sex differences (P<0.05) in the following regions: dorsal raphe, amygdala, anterior cingulate, cingulate body, medial PFC, and orbital PFC. The cerebellar volume of distribution was also significantly higher in females. There is a significant negative correlation between binding in several regions and lifetime aggression. We have replicated our post-mortem finding of higher 5-HT(1A) binding in females compared to males. We did not detect an age dependent decrease in binding in males or females. Lower 5-HT(1A) binding in more aggressive individuals is consistent with pharmacological challenge studies. Future studies should determine whether the binding is a state or trait effect.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0006-8993
pubmed:author
pubmed:copyrightInfo
Copyright 2002 Elsevier Science B.V.
pubmed:issnType
Print
pubmed:day
8
pubmed:volume
954
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
173-82
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:12414100-Adult, pubmed-meshheading:12414100-Aggression, pubmed-meshheading:12414100-Aging, pubmed-meshheading:12414100-Amygdala, pubmed-meshheading:12414100-Brain, pubmed-meshheading:12414100-Carbon Radioisotopes, pubmed-meshheading:12414100-Cerebellum, pubmed-meshheading:12414100-Female, pubmed-meshheading:12414100-Gyrus Cinguli, pubmed-meshheading:12414100-Hippocampus, pubmed-meshheading:12414100-Humans, pubmed-meshheading:12414100-Image Processing, Computer-Assisted, pubmed-meshheading:12414100-Male, pubmed-meshheading:12414100-Middle Aged, pubmed-meshheading:12414100-Piperazines, pubmed-meshheading:12414100-Prefrontal Cortex, pubmed-meshheading:12414100-Pyridines, pubmed-meshheading:12414100-Raphe Nuclei, pubmed-meshheading:12414100-Receptors, Serotonin, pubmed-meshheading:12414100-Reference Values, pubmed-meshheading:12414100-Serotonin Antagonists, pubmed-meshheading:12414100-Sex Characteristics, pubmed-meshheading:12414100-Tomography, Emission-Computed
pubmed:year
2002
pubmed:articleTitle
Effects of sex, age, and aggressive traits in man on brain serotonin 5-HT1A receptor binding potential measured by PET using [C-11]WAY-100635.
pubmed:affiliation
Division of Neuroscience, Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA. rparsey@neuron.cpmc.columbia.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.