Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2002-11-4
pubmed:abstractText
The present study compared the safety of 4.5 microg formoterol with 0.5 mg terbutaline, both by Turbuhaler and used as needed, in addition to regular formoterol in moderate asthma. In this double-blind parallel-group study, 357 patients taking a moderate-to-high dose of inhaled corticosteroids and additional terbutaline (2-5 inhalations x day(-1) during run-in) were randomised to either formoterol or terbutaline as needed in addition to formoterol 9 microg b.i.d. over 12 weeks. Adverse events, serum potassium levels, electrocardiogram, vital signs and lung function were assessed monthly; peak expiratory flow and severe asthma exacerbations were recorded daily. Patients used 2.16 (range 0.0-6.3) formoterol and 2.34 (range 0.1-7.5) terbutaline relief inhalations x day(-1). No clinically significant differences in safety variables were found between treatments. Statistically greater increases in cardiac frequency (2.6 beats x min(-1), p=0.03) were found on terbutaline. There were 44 and 52 severe asthma exacerbations with formoterol and terbutaline, respectively, with no significant difference in time to first exacerbation. There was also no difference between treatments for other efficacy measures (peak expiratory flow, forced expiratory volume in one second and morning/evening symptom scores). Formoterol 4.5 microg as needed was at least as safe, well tolerated and effective as terbutaline 0.5 mg in stable patients (requiring up to 6 relief inhalations x day(-1)) taking formoterol plus inhaled corticosteroids regularly over 12 weeks.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0903-1936
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
859-66
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:12412676-Administration, Inhalation, pubmed-meshheading:12412676-Adrenal Cortex Hormones, pubmed-meshheading:12412676-Adult, pubmed-meshheading:12412676-Asthma, pubmed-meshheading:12412676-Dose-Response Relationship, Drug, pubmed-meshheading:12412676-Double-Blind Method, pubmed-meshheading:12412676-Drug Administration Schedule, pubmed-meshheading:12412676-Drug Therapy, Combination, pubmed-meshheading:12412676-Ethanolamines, pubmed-meshheading:12412676-Female, pubmed-meshheading:12412676-Follow-Up Studies, pubmed-meshheading:12412676-Humans, pubmed-meshheading:12412676-Male, pubmed-meshheading:12412676-Middle Aged, pubmed-meshheading:12412676-Nebulizers and Vaporizers, pubmed-meshheading:12412676-Probability, pubmed-meshheading:12412676-Respiratory Function Tests, pubmed-meshheading:12412676-Sensitivity and Specificity, pubmed-meshheading:12412676-Severity of Illness Index, pubmed-meshheading:12412676-Statistics, Nonparametric, pubmed-meshheading:12412676-Terbutaline, pubmed-meshheading:12412676-Treatment Outcome
pubmed:year
2002
pubmed:articleTitle
Safety of formoterol by Turbuhaler as reliever medication compared with terbutaline in moderate asthma.
pubmed:affiliation
Respiratory Medicine Unit, ICSM at the National Heart and Lung Institute, Hammersmith Hospital, London, UK. p.ind@ic.ac.uk
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't