Linked Life Data

12408960

Source:http://linkedlifedata.com/resource/pubmed/id/12408960

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2002-10-31
pubmed:abstractText
A significant fraction of the human genome is composed of various types of transposable elements, which are divided into two broad classes based on their mehcanism of transposition: via an RNA intermediate (retroelements) or via a DNA intermediate (DNA transposons). The retroelements, which include endogenous retroviruses, are the more prominent group in humans and seem to be restricted to eukaryotes. DNA transposons are known in almost all well-studied organisms, including bacteria. In the human genome, they exist as mere fossils and seem to have been inactive for millions of years. We report here an element in the human genome that is the product of a recent retrotransposition event, yet apparently, by a novel mechanism of reverse transcription, has acquired inverted repeats more characteristic of DNA transposons.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0888-7543
pubmed:author
pubmed:issnType
Print
pubmed:volume
80
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
453-5
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
A novel endogenous retrovirus-related element in the human genome resembles a DNA transposon: evidence for an evolutionary link?
pubmed:affiliation
Department of Molecular Biology and Microbiology and Program in Genetics, Tufts University School of Medicine, 136 Harrison Avenue, Boston, Massachusetts, 02111, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.