Source:http://linkedlifedata.com/resource/pubmed/id/12408854
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2002-10-31
|
| pubmed:abstractText |
Cellular theories of memory consolidation posit that new memories require new protein synthesis in order to be stored. Systems consolidation theories posit that the hippocampus has a time-limited role in memory storage, after which the memory is independent of the hippocampus. Here, we show that intra-hippocampal infusions of the protein synthesis inhibitor anisomycin caused amnesia for a consolidated hippocampal-dependent contextual fear memory, but only if the memory was reactivated prior to infusion. The effect occurred even if reactivation was delayed for 45 days after training, a time when contextual memory is independent of the hippocampus. Indeed, reactivation of a hippocampus-independent memory caused the trace to again become hippocampus dependent, but only for 2 days rather than for weeks. Thus, hippocampal memories can undergo reconsolidation at both the cellular and systems levels.
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| pubmed:grant | |
| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
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| pubmed:issn |
0896-6273
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
24
|
| pubmed:volume |
36
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
527-38
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| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:12408854-Amnesia, Retrograde,
pubmed-meshheading:12408854-Animals,
pubmed-meshheading:12408854-Anisomycin,
pubmed-meshheading:12408854-Conditioning (Psychology),
pubmed-meshheading:12408854-Fear,
pubmed-meshheading:12408854-Hippocampus,
pubmed-meshheading:12408854-Male,
pubmed-meshheading:12408854-Memory,
pubmed-meshheading:12408854-Memory, Short-Term,
pubmed-meshheading:12408854-Memory Disorders,
pubmed-meshheading:12408854-Models, Neurological,
pubmed-meshheading:12408854-Nerve Tissue Proteins,
pubmed-meshheading:12408854-Neural Pathways,
pubmed-meshheading:12408854-Neurons,
pubmed-meshheading:12408854-Protein Synthesis Inhibitors,
pubmed-meshheading:12408854-Rats,
pubmed-meshheading:12408854-Rats, Sprague-Dawley,
pubmed-meshheading:12408854-Reaction Time,
pubmed-meshheading:12408854-Time Factors
|
| pubmed:year |
2002
|
| pubmed:articleTitle |
Cellular and systems reconsolidation in the hippocampus.
|
| pubmed:affiliation |
Department of Psychiatry, Jagiellonian University Collegium Medicum, 31-501, Cracow, Poland.
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|