| pubmed-article:12405833 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12405833 | lifeskim:mentions | umls-concept:C0026837 | lld:lifeskim |
| pubmed-article:12405833 | lifeskim:mentions | umls-concept:C1336776 | lld:lifeskim |
| pubmed-article:12405833 | lifeskim:mentions | umls-concept:C1707689 | lld:lifeskim |
| pubmed-article:12405833 | lifeskim:mentions | umls-concept:C2004457 | lld:lifeskim |
| pubmed-article:12405833 | lifeskim:mentions | umls-concept:C0231517 | lld:lifeskim |
| pubmed-article:12405833 | pubmed:issue | 44 | lld:pubmed |
| pubmed-article:12405833 | pubmed:dateCreated | 2002-10-30 | lld:pubmed |
| pubmed-article:12405833 | pubmed:abstractText | Typical eukaryotic transcriptional activators are composed of distinct functional domains, including a DNA binding domain and an activating domain. Artificial transcription factors have been designed wherein the DNA binding domain is a minor groove DNA binding hairpin polyamide linked by a flexible tether to short activating peptides, typically 16-20 residues in size. In this study, the linker between the polyamide and the peptide was altered in an incremental fashion using rigid oligoproline "molecular rulers" in the 18-45 A length range. We find that there is an optimal linker length which separates the DNA and the activation region for transcription activation. | lld:pubmed |
| pubmed-article:12405833 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12405833 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12405833 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12405833 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12405833 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12405833 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12405833 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12405833 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12405833 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12405833 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:12405833 | pubmed:issn | 0002-7863 | lld:pubmed |
| pubmed-article:12405833 | pubmed:author | pubmed-author:DervanPeter... | lld:pubmed |
| pubmed-article:12405833 | pubmed:author | pubmed-author:PtashneMarkM | lld:pubmed |
| pubmed-article:12405833 | pubmed:author | pubmed-author:AnsariAseem... | lld:pubmed |
| pubmed-article:12405833 | pubmed:author | pubmed-author:AroraParamjit... | lld:pubmed |
| pubmed-article:12405833 | pubmed:author | pubmed-author:BestTimothy... | lld:pubmed |
| pubmed-article:12405833 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12405833 | pubmed:day | 6 | lld:pubmed |
| pubmed-article:12405833 | pubmed:volume | 124 | lld:pubmed |
| pubmed-article:12405833 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12405833 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12405833 | pubmed:pagination | 13067-71 | lld:pubmed |
| pubmed-article:12405833 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:12405833 | pubmed:meshHeading | pubmed-meshheading:12405833... | lld:pubmed |
| pubmed-article:12405833 | pubmed:meshHeading | pubmed-meshheading:12405833... | lld:pubmed |
| pubmed-article:12405833 | pubmed:meshHeading | pubmed-meshheading:12405833... | lld:pubmed |
| pubmed-article:12405833 | pubmed:meshHeading | pubmed-meshheading:12405833... | lld:pubmed |
| pubmed-article:12405833 | pubmed:meshHeading | pubmed-meshheading:12405833... | lld:pubmed |
| pubmed-article:12405833 | pubmed:meshHeading | pubmed-meshheading:12405833... | lld:pubmed |
| pubmed-article:12405833 | pubmed:meshHeading | pubmed-meshheading:12405833... | lld:pubmed |
| pubmed-article:12405833 | pubmed:meshHeading | pubmed-meshheading:12405833... | lld:pubmed |
| pubmed-article:12405833 | pubmed:meshHeading | pubmed-meshheading:12405833... | lld:pubmed |
| pubmed-article:12405833 | pubmed:meshHeading | pubmed-meshheading:12405833... | lld:pubmed |
| pubmed-article:12405833 | pubmed:meshHeading | pubmed-meshheading:12405833... | lld:pubmed |
| pubmed-article:12405833 | pubmed:meshHeading | pubmed-meshheading:12405833... | lld:pubmed |
| pubmed-article:12405833 | pubmed:meshHeading | pubmed-meshheading:12405833... | lld:pubmed |
| pubmed-article:12405833 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12405833 | pubmed:articleTitle | Design of artificial transcriptional activators with rigid poly-L-proline linkers. | lld:pubmed |
| pubmed-article:12405833 | pubmed:affiliation | Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA. | lld:pubmed |
| pubmed-article:12405833 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12405833 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12405833 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12405833 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12405833 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12405833 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12405833 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12405833 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12405833 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12405833 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12405833 | lld:pubmed |
