Linked Life Data

12397685

Source:http://linkedlifedata.com/resource/pubmed/id/12397685

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2002-10-25
pubmed:abstractText
The natriuretic peptide comprises at least three ligands(ANP, BNP, and CNP) and three receptors(GC-A, GC-B, and Clearance receptor). ANP and BNP are cardiac hormones, which regulate blood pressure and body fluid volume. Angiotensin II, the effector peptide of the renin-angiotensin system, regulates cellular growth in response to developmental, physiological and pathological processes. Recently, evidences suggest that cardiovascular homeostasis is determined by the balance between these two important counter-regulatory pathways. In this paper, we will discuss the molecular mechanism of the cross-talk between the two systems, including our recent findings using the mice deficient for GC-A and angiotensin II receptors. The results suggest that the endogenous natriuretic peptide system inhibits the cardiac angiotensin system and protects the heart from excessive pathological remodelings.
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0047-1852
pubmed:author
pubmed:issnType
Print
pubmed:volume
60
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1923-8
pubmed:dateRevised
2011-7-27
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
[Cross-talk between the natriuretic peptide system and the angiotensin system].
pubmed:affiliation
Kyoto University School of Medicine, Department of Medicine and Clinical Science.
pubmed:publicationType
Journal Article, English Abstract, Review