| pubmed-article:12397177 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12397177 | lifeskim:mentions | umls-concept:C0015576 | lld:lifeskim |
| pubmed-article:12397177 | lifeskim:mentions | umls-concept:C0040648 | lld:lifeskim |
| pubmed-article:12397177 | lifeskim:mentions | umls-concept:C0074398 | lld:lifeskim |
| pubmed-article:12397177 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:12397177 | lifeskim:mentions | umls-concept:C0279023 | lld:lifeskim |
| pubmed-article:12397177 | pubmed:dateCreated | 2002-11-13 | lld:pubmed |
| pubmed-article:12397177 | pubmed:abstractText | Myocardin is a SAP (SAF-A/B, Acinus, PIAS) domain transcription factor that associates with serum response factor (SRF) to potently enhance SRF-dependent transcription. Here we describe two myocardin-related transcription factors (MRTFs), A and B, that also interact with SRF and stimulate its transcriptional activity. Whereas myocardin is expressed specifically in cardiac and smooth muscle cells, MRTF-A and -B are expressed in numerous embryonic and adult tissues. In SRF-deficient embryonic stem cells, myocardin and MRTFs are unable to activate SRF-dependent reporter genes, confirming their dependence on SRF. Myocardin and MRTFs comprise a previously uncharacterized family of SRF cofactors with the potential to modulate SRF target genes in a wide range of tissues. | lld:pubmed |
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| pubmed-article:12397177 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12397177 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12397177 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12397177 | pubmed:author | pubmed-author:RichardsonJam... | lld:pubmed |
| pubmed-article:12397177 | pubmed:author | pubmed-author:OlsonEric NEN | lld:pubmed |
| pubmed-article:12397177 | pubmed:author | pubmed-author:SchrattGerhar... | lld:pubmed |
| pubmed-article:12397177 | pubmed:author | pubmed-author:NordheimAlfre... | lld:pubmed |
| pubmed-article:12397177 | pubmed:author | pubmed-author:WangDa-ZhiDZ | lld:pubmed |
| pubmed-article:12397177 | pubmed:author | pubmed-author:LiShijieS | lld:pubmed |
| pubmed-article:12397177 | pubmed:author | pubmed-author:HockemeyerDir... | lld:pubmed |
| pubmed-article:12397177 | pubmed:author | pubmed-author:SutherlandLil... | lld:pubmed |
| pubmed-article:12397177 | pubmed:author | pubmed-author:WangZhigaoZ | lld:pubmed |
| pubmed-article:12397177 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12397177 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12397177 | pubmed:pagination | 14855-60 | lld:pubmed |
| pubmed-article:12397177 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:12397177 | pubmed:articleTitle | Potentiation of serum response factor activity by a family of myocardin-related transcription factors. | lld:pubmed |
| pubmed-article:12397177 | pubmed:affiliation | Department of Molecular Biology, University of Texas, Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas 75390-9148, USA. | lld:pubmed |
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