Source:http://linkedlifedata.com/resource/pubmed/id/12395925
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
2002-10-24
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| pubmed:abstractText |
One hallmark of neoplasia is abnormal differentiation. Induction of differentiation, by chemical or biological methods, provides a possible therapeutic intervention. "Differentiation therapy" is well documented in several model systems. These include melanoma, in which treatment with interferon-beta and the protein kinase C activator mezerein induces irreversible growth arrest and terminal differentiation culminating in programmed cell death. Subtraction hybridization between terminally differentiated and untreated melanoma cells identified melanoma differentiation-associated gene-7 (mda-7), which is selectively induced during the process of melanoma terminal differentiation. Since its identification seven years ago, mda-7 has been the object of intense focus because of its unique biological properties. Firstly, mda-7 is a secreted protein having cytokine-like properties and belonging to the IL-10 cytokine family. Based on this consideration, mda-7 was renamed IL-24. Secondly if delivered by means of an adenoviral vector, mda-7 induces selective apoptosis in cancer cells of diverse origin, while sparing their normal cellular counterparts. As such, mda-7 has become a novel tool for cancer gene therapy and is currently undergoing phase II clinical trials to determine its clinical efficacy in patients. The present review examines the biological properties of mda-7 and the signaling pathways that contribute to its unique cancer-specific apoptosis-inducing properties.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Angiogenesis Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukins,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/interleukin-24
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| pubmed:status |
MEDLINE
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| pubmed:month |
Oct
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| pubmed:issn |
0736-6205
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
Suppl
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
30-9
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| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:12395925-Angiogenesis Inhibitors,
pubmed-meshheading:12395925-Animals,
pubmed-meshheading:12395925-Apoptosis,
pubmed-meshheading:12395925-Cell Differentiation,
pubmed-meshheading:12395925-Chromosomes, Human, Pair 1,
pubmed-meshheading:12395925-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:12395925-Gene Therapy,
pubmed-meshheading:12395925-Genes, Tumor Suppressor,
pubmed-meshheading:12395925-Humans,
pubmed-meshheading:12395925-Interleukins,
pubmed-meshheading:12395925-Mammals,
pubmed-meshheading:12395925-Melanoma,
pubmed-meshheading:12395925-Mice,
pubmed-meshheading:12395925-Neoplasm Proteins,
pubmed-meshheading:12395925-Neoplasms,
pubmed-meshheading:12395925-Pancreatic Neoplasms,
pubmed-meshheading:12395925-Rats,
pubmed-meshheading:12395925-Recombinant Fusion Proteins,
pubmed-meshheading:12395925-Safety,
pubmed-meshheading:12395925-Signal Transduction,
pubmed-meshheading:12395925-Tumor Cells, Cultured
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| pubmed:year |
2002
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| pubmed:articleTitle |
mda-7 (IL-24): signaling and functional roles.
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| pubmed:affiliation |
Department of Pathology, Herbert Irving Comprehensive Cancer Center, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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