| pubmed-article:12393936 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12393936 | lifeskim:mentions | umls-concept:C1704263 | lld:lifeskim |
| pubmed-article:12393936 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:12393936 | lifeskim:mentions | umls-concept:C2266856 | lld:lifeskim |
| pubmed-article:12393936 | lifeskim:mentions | umls-concept:C0243071 | lld:lifeskim |
| pubmed-article:12393936 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:12393936 | pubmed:dateCreated | 2002-10-23 | lld:pubmed |
| pubmed-article:12393936 | pubmed:abstractText | Animal, epidemiological and clinical studies have demonstrated the anti-tumor activity of pharmacological proteasome inhibitors and the cancer-preventive effects of green tea consumption. Previously, one of our laboratories reported that natural ester bond-containing green tea polyphenols (GTPs), such as (-)-epigallocatechin-3-gallate [(-)-EGCG] and (-)-gallocatechin-3-gallate [(-)-GCG], are potent and specific proteasome inhibitors. Another of our groups, for the first time, was able to enantioselectively synthesize (-)-EGCG as well as other analogs of this natural GTP. Our interest in designing and developing novel synthetic GTPs as proteasome inhibitors and potential cancer-preventive agents prompted our current study. | lld:pubmed |
| pubmed-article:12393936 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:12393936 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12393936 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12393936 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:12393936 | pubmed:issn | 1076-1551 | lld:pubmed |
| pubmed-article:12393936 | pubmed:author | pubmed-author:WangZhigangZ | lld:pubmed |
| pubmed-article:12393936 | pubmed:author | pubmed-author:SmithDavid... | lld:pubmed |
| pubmed-article:12393936 | pubmed:author | pubmed-author:LiLian-HaiLH | lld:pubmed |
| pubmed-article:12393936 | pubmed:author | pubmed-author:KaziAslamuzza... | lld:pubmed |
| pubmed-article:12393936 | pubmed:author | pubmed-author:DouQ PingQP | lld:pubmed |
| pubmed-article:12393936 | pubmed:author | pubmed-author:ChanTak-HangT... | lld:pubmed |
| pubmed-article:12393936 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12393936 | pubmed:volume | 8 | lld:pubmed |
| pubmed-article:12393936 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12393936 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12393936 | pubmed:pagination | 382-92 | lld:pubmed |
| pubmed-article:12393936 | pubmed:dateRevised | 2008-11-20 | lld:pubmed |
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| pubmed-article:12393936 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12393936 | pubmed:articleTitle | Synthetic analogs of green tea polyphenols as proteasome inhibitors. | lld:pubmed |
| pubmed-article:12393936 | pubmed:affiliation | Drug Discovery Program, H Lee Moffitt Cancer Center & Research Institute, Departments of Interdisciplinary Oncology and Biochemistry & Molecular Biology, College of Medicine,University of South Florida, Tampa, FL 33612-9497, USA. | lld:pubmed |
| pubmed-article:12393936 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12393936 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:12393936 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:12393936 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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