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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2002-10-23
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pubmed:abstractText |
Animal, epidemiological and clinical studies have demonstrated the anti-tumor activity of pharmacological proteasome inhibitors and the cancer-preventive effects of green tea consumption. Previously, one of our laboratories reported that natural ester bond-containing green tea polyphenols (GTPs), such as (-)-epigallocatechin-3-gallate [(-)-EGCG] and (-)-gallocatechin-3-gallate [(-)-GCG], are potent and specific proteasome inhibitors. Another of our groups, for the first time, was able to enantioselectively synthesize (-)-EGCG as well as other analogs of this natural GTP. Our interest in designing and developing novel synthetic GTPs as proteasome inhibitors and potential cancer-preventive agents prompted our current study.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/BAX protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Calpain,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Caspases,
http://linkedlifedata.com/resource/pubmed/chemical/Cysteine Endopeptidases,
http://linkedlifedata.com/resource/pubmed/chemical/Guanosine Triphosphate,
http://linkedlifedata.com/resource/pubmed/chemical/IKBKAP protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Ikbkap protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Microfilament Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Multienzyme Complexes,
http://linkedlifedata.com/resource/pubmed/chemical/Muscle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Phenols,
http://linkedlifedata.com/resource/pubmed/chemical/Polymers,
http://linkedlifedata.com/resource/pubmed/chemical/Proteasome Endopeptidase Complex,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-bcl-2,
http://linkedlifedata.com/resource/pubmed/chemical/Tagln protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Tea,
http://linkedlifedata.com/resource/pubmed/chemical/bcl-2-Associated X Protein
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1076-1551
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
382-92
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pubmed:dateRevised |
2008-11-20
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pubmed:meshHeading |
pubmed-meshheading:12393936-Adenocarcinoma,
pubmed-meshheading:12393936-Apoptosis,
pubmed-meshheading:12393936-Calpain,
pubmed-meshheading:12393936-Carcinoma,
pubmed-meshheading:12393936-Carrier Proteins,
pubmed-meshheading:12393936-Caspases,
pubmed-meshheading:12393936-Cell Line,
pubmed-meshheading:12393936-Cysteine Endopeptidases,
pubmed-meshheading:12393936-G1 Phase,
pubmed-meshheading:12393936-Guanosine Triphosphate,
pubmed-meshheading:12393936-Humans,
pubmed-meshheading:12393936-Jurkat Cells,
pubmed-meshheading:12393936-Male,
pubmed-meshheading:12393936-Microfilament Proteins,
pubmed-meshheading:12393936-Multienzyme Complexes,
pubmed-meshheading:12393936-Muscle Proteins,
pubmed-meshheading:12393936-Phenols,
pubmed-meshheading:12393936-Polymers,
pubmed-meshheading:12393936-Prostatic Neoplasms,
pubmed-meshheading:12393936-Proteasome Endopeptidase Complex,
pubmed-meshheading:12393936-Proto-Oncogene Proteins,
pubmed-meshheading:12393936-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:12393936-Stereoisomerism,
pubmed-meshheading:12393936-Tea,
pubmed-meshheading:12393936-bcl-2-Associated X Protein
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pubmed:year |
2002
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pubmed:articleTitle |
Synthetic analogs of green tea polyphenols as proteasome inhibitors.
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pubmed:affiliation |
Drug Discovery Program, H Lee Moffitt Cancer Center & Research Institute, Departments of Interdisciplinary Oncology and Biochemistry & Molecular Biology, College of Medicine,University of South Florida, Tampa, FL 33612-9497, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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