| pubmed-article:12392915 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12392915 | lifeskim:mentions | umls-concept:C0041234 | lld:lifeskim |
| pubmed-article:12392915 | lifeskim:mentions | umls-concept:C1522564 | lld:lifeskim |
| pubmed-article:12392915 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:12392915 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:12392915 | lifeskim:mentions | umls-concept:C0678594 | lld:lifeskim |
| pubmed-article:12392915 | lifeskim:mentions | umls-concept:C0070915 | lld:lifeskim |
| pubmed-article:12392915 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:12392915 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:12392915 | pubmed:dateCreated | 2002-10-23 | lld:pubmed |
| pubmed-article:12392915 | pubmed:abstractText | Chagas' disease is an important cause of cardiomyopathy. Endothelin-1, a vasoactive peptide has been implicated in the pathogenesis of chagasic cardiomyopathy. C57BL/6 x 129sv and CD1 mice were thus, infected with trypomastigotes of Trypanosoma cruzi (Brazil strain) and these infected mice were compared with infected mice treated with phosphoramidon. This compound inhibits endothelin-converting enzyme and neutral endopeptidases and does not affect the growth of the parasite in culture. Phosphoramidon was given in a dose of 10mg/kg for the initial 15 days post-infection None of the C57Bl/6 x 129sv mice died as a result of infection. However, there was marked myocardial inflammation and fibrosis in infected, untreated mice. The hearts of the infected, phosphoramidon-treated mice showed significantly less pathology. Cardiac magnetic resonance imaging of infected mice revealed right ventricular dilation that was less severe in those treated with phosphoramidon. Phosphoramidon-treated CD1 mice survived the acute infection. Transthoracic echocardiography demonstrated left ventricular dilation and reduced percent fractional shortening and relative wall thickness. These alterations were also attenuated as a result of phosphoramidon treatment. These data suggest that endothelin-1 contributes to the pathogenesis of chagasic cardiomyopathy and interventions that inhibit the synthesis of endothelin-1 and/or neutral endopeptidase might have a protective effect on myocardial structure and function in murine Chagas' disease. | lld:pubmed |
| pubmed-article:12392915 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12392915 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12392915 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12392915 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12392915 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12392915 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12392915 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12392915 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12392915 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12392915 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:12392915 | pubmed:issn | 0020-7519 | lld:pubmed |
| pubmed-article:12392915 | pubmed:author | pubmed-author:TeixeiraMauro... | lld:pubmed |
| pubmed-article:12392915 | pubmed:author | pubmed-author:JelicksLinda... | lld:pubmed |
| pubmed-article:12392915 | pubmed:author | pubmed-author:TangBaiyuB | lld:pubmed |
| pubmed-article:12392915 | pubmed:author | pubmed-author:WeissLouis... | lld:pubmed |
| pubmed-article:12392915 | pubmed:author | pubmed-author:WittnerMurray... | lld:pubmed |
| pubmed-article:12392915 | pubmed:author | pubmed-author:FactorStephen... | lld:pubmed |
| pubmed-article:12392915 | pubmed:author | pubmed-author:ChandraMadhul... | lld:pubmed |
| pubmed-article:12392915 | pubmed:author | pubmed-author:ShiraniJamshi... | lld:pubmed |
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| pubmed-article:12392915 | pubmed:author | pubmed-author:ChristGeorge... | lld:pubmed |
| pubmed-article:12392915 | pubmed:author | pubmed-author:DouglasStephe... | lld:pubmed |
| pubmed-article:12392915 | pubmed:author | pubmed-author:HuangHuanH | lld:pubmed |
| pubmed-article:12392915 | pubmed:author | pubmed-author:MukherjeeShan... | lld:pubmed |
| pubmed-article:12392915 | pubmed:author | pubmed-author:BouzahzahBoum... | lld:pubmed |
| pubmed-article:12392915 | pubmed:author | pubmed-author:LoredoMaria... | lld:pubmed |
| pubmed-article:12392915 | pubmed:author | pubmed-author:D'Orleans-Jus... | lld:pubmed |
| pubmed-article:12392915 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12392915 | pubmed:volume | 32 | lld:pubmed |
| pubmed-article:12392915 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12392915 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12392915 | pubmed:pagination | 1497-506 | lld:pubmed |
| pubmed-article:12392915 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:12392915 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12392915 | pubmed:articleTitle | Cardioprotective effects of phosphoramidon on myocardial structure and function in murine Chagas' disease. | lld:pubmed |
| pubmed-article:12392915 | pubmed:affiliation | Department of Physiology and Biophysics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA. | lld:pubmed |
| pubmed-article:12392915 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12392915 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12392915 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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