Source:http://linkedlifedata.com/resource/pubmed/id/12392915
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
12
|
| pubmed:dateCreated |
2002-10-23
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| pubmed:abstractText |
Chagas' disease is an important cause of cardiomyopathy. Endothelin-1, a vasoactive peptide has been implicated in the pathogenesis of chagasic cardiomyopathy. C57BL/6 x 129sv and CD1 mice were thus, infected with trypomastigotes of Trypanosoma cruzi (Brazil strain) and these infected mice were compared with infected mice treated with phosphoramidon. This compound inhibits endothelin-converting enzyme and neutral endopeptidases and does not affect the growth of the parasite in culture. Phosphoramidon was given in a dose of 10mg/kg for the initial 15 days post-infection None of the C57Bl/6 x 129sv mice died as a result of infection. However, there was marked myocardial inflammation and fibrosis in infected, untreated mice. The hearts of the infected, phosphoramidon-treated mice showed significantly less pathology. Cardiac magnetic resonance imaging of infected mice revealed right ventricular dilation that was less severe in those treated with phosphoramidon. Phosphoramidon-treated CD1 mice survived the acute infection. Transthoracic echocardiography demonstrated left ventricular dilation and reduced percent fractional shortening and relative wall thickness. These alterations were also attenuated as a result of phosphoramidon treatment. These data suggest that endothelin-1 contributes to the pathogenesis of chagasic cardiomyopathy and interventions that inhibit the synthesis of endothelin-1 and/or neutral endopeptidase might have a protective effect on myocardial structure and function in murine Chagas' disease.
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| pubmed:grant | |
| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Nov
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| pubmed:issn |
0020-7519
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| pubmed:author |
pubmed-author:BouzahzahBoumedieneB,
pubmed-author:ChandraMadhulikaM,
pubmed-author:ChristGeorge JGJ,
pubmed-author:D'Orleans-JustePedroP,
pubmed-author:DouglasStephen ASA,
pubmed-author:FactorStephen MSM,
pubmed-author:HuangHuanH,
pubmed-author:JelicksLinda ALA,
pubmed-author:LoredoMaria LML,
pubmed-author:MukherjeeShankarS,
pubmed-author:PetkovaStefka BSB,
pubmed-author:ShiraniJamshidJ,
pubmed-author:ShtutinVitaliyV,
pubmed-author:TangBaiyuB,
pubmed-author:TanowitzHerbert BHB,
pubmed-author:TeixeiraMauro MMM,
pubmed-author:WeissLouis MLM,
pubmed-author:WittnerMurrayM
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| pubmed:issnType |
Print
|
| pubmed:volume |
32
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1497-506
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| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:12392915-Animals,
pubmed-meshheading:12392915-Chagas Cardiomyopathy,
pubmed-meshheading:12392915-Disease Models, Animal,
pubmed-meshheading:12392915-Echocardiography,
pubmed-meshheading:12392915-Gene Expression Regulation,
pubmed-meshheading:12392915-Glycopeptides,
pubmed-meshheading:12392915-Heart,
pubmed-meshheading:12392915-Magnetic Resonance Imaging,
pubmed-meshheading:12392915-Male,
pubmed-meshheading:12392915-Mice,
pubmed-meshheading:12392915-Mice, Inbred Strains,
pubmed-meshheading:12392915-Myocardium,
pubmed-meshheading:12392915-Protease Inhibitors,
pubmed-meshheading:12392915-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:12392915-Trypanosoma cruzi
|
| pubmed:year |
2002
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| pubmed:articleTitle |
Cardioprotective effects of phosphoramidon on myocardial structure and function in murine Chagas' disease.
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| pubmed:affiliation |
Department of Physiology and Biophysics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|