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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
22
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pubmed:dateCreated |
2002-10-23
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pubmed:abstractText |
A focused SAR study around the previously reported selective 5-HT(7) receptor antagonist, SB-269970-A has resulted in the identification of a structurally related analogue having an improved pharmacokinetic profile. Replacement of the phenolic group in SB-269970-A with an indole moiety, and replacement of the piperidinyl 4-methyl group with a heterocyclic ring system proved to be the key changes leading to the identification of SB-656104-A.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0960-894X
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pubmed:author |
pubmed-author:DouglasSaraS,
pubmed-author:ForbesIan TIT,
pubmed-author:GarnerAshley EAE,
pubmed-author:GribbleAndrew DAD,
pubmed-author:IfeRobert JRJ,
pubmed-author:JeffreyPhillipP,
pubmed-author:LightfootAndrew PAP,
pubmed-author:RileyGraham JGJ,
pubmed-author:SteanTania OTO,
pubmed-author:StevensAlexander JAJ,
pubmed-author:ThomasDavid RDR
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pubmed:issnType |
Print
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pubmed:day |
18
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3341-4
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12392747-Animals,
pubmed-meshheading:12392747-Blood-Brain Barrier,
pubmed-meshheading:12392747-Heterocyclic Compounds,
pubmed-meshheading:12392747-Indoles,
pubmed-meshheading:12392747-Phenols,
pubmed-meshheading:12392747-Protein Binding,
pubmed-meshheading:12392747-Pyrrolidines,
pubmed-meshheading:12392747-Rats,
pubmed-meshheading:12392747-Receptors, Serotonin,
pubmed-meshheading:12392747-Serotonin Antagonists,
pubmed-meshheading:12392747-Structure-Activity Relationship,
pubmed-meshheading:12392747-Sulfonamides
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pubmed:year |
2002
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pubmed:articleTitle |
SB-656104-A: a novel 5-HT(7) receptor antagonist with improved in vivo properties.
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pubmed:affiliation |
GlaxoSmithKline, New Frontiers Science Park, Harlow, Essex, UK. ian_t_forbes@gsk.com
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pubmed:publicationType |
Journal Article,
Comparative Study
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