Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
22
pubmed:dateCreated
2002-10-30
pubmed:abstractText
The kinesin superfamily proteins (KIFs) play essential roles in receptor transportation along the microtubules. KIF17 transports the N-methyl-d-aspartate receptor NR2B subunit in vitro, but its role in vivo is unknown. To clarify this role, we generated transgenic mice overexpressing KIF17 tagged with GFP. The KIF17 transgenic mice exhibited enhanced learning and memory in a series of behavioral tasks, up-regulated NR2B expression with the potential involvement of a transcriptional factor, the cAMP-dependent response element-binding protein, and increased phosphorylation of the cAMP-dependent response element-binding protein. Our results suggest that the motor protein KIF17 contributes to neuronal events required for learning and memory by trafficking fundamental N-methyl-d-aspartate-type glutamate receptors.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/12391294-10357226, http://linkedlifedata.com/resource/pubmed/commentcorrection/12391294-10485705, http://linkedlifedata.com/resource/pubmed/commentcorrection/12391294-10529810, http://linkedlifedata.com/resource/pubmed/commentcorrection/12391294-10748057, http://linkedlifedata.com/resource/pubmed/commentcorrection/12391294-10846156, http://linkedlifedata.com/resource/pubmed/commentcorrection/12391294-10908628, http://linkedlifedata.com/resource/pubmed/commentcorrection/12391294-10911623, http://linkedlifedata.com/resource/pubmed/commentcorrection/12391294-10949829, http://linkedlifedata.com/resource/pubmed/commentcorrection/12391294-11001946, http://linkedlifedata.com/resource/pubmed/commentcorrection/12391294-11084318, http://linkedlifedata.com/resource/pubmed/commentcorrection/12391294-11140684, http://linkedlifedata.com/resource/pubmed/commentcorrection/12391294-11243595, http://linkedlifedata.com/resource/pubmed/commentcorrection/12391294-11266574, http://linkedlifedata.com/resource/pubmed/commentcorrection/12391294-11416179, http://linkedlifedata.com/resource/pubmed/commentcorrection/12391294-11483993, http://linkedlifedata.com/resource/pubmed/commentcorrection/12391294-11571036, http://linkedlifedata.com/resource/pubmed/commentcorrection/12391294-11572782, http://linkedlifedata.com/resource/pubmed/commentcorrection/12391294-11691980, http://linkedlifedata.com/resource/pubmed/commentcorrection/12391294-11733061, http://linkedlifedata.com/resource/pubmed/commentcorrection/12391294-11752651, http://linkedlifedata.com/resource/pubmed/commentcorrection/12391294-11889468, http://linkedlifedata.com/resource/pubmed/commentcorrection/12391294-11893339, http://linkedlifedata.com/resource/pubmed/commentcorrection/12391294-11988169, http://linkedlifedata.com/resource/pubmed/commentcorrection/12391294-11988175, http://linkedlifedata.com/resource/pubmed/commentcorrection/12391294-12186847, http://linkedlifedata.com/resource/pubmed/commentcorrection/12391294-1329206, http://linkedlifedata.com/resource/pubmed/commentcorrection/12391294-1350383, http://linkedlifedata.com/resource/pubmed/commentcorrection/12391294-1447303, http://linkedlifedata.com/resource/pubmed/commentcorrection/12391294-15157476, http://linkedlifedata.com/resource/pubmed/commentcorrection/12391294-2412134, http://linkedlifedata.com/resource/pubmed/commentcorrection/12391294-2522351, http://linkedlifedata.com/resource/pubmed/commentcorrection/12391294-3926325, http://linkedlifedata.com/resource/pubmed/commentcorrection/12391294-522981, http://linkedlifedata.com/resource/pubmed/commentcorrection/12391294-6181077, http://linkedlifedata.com/resource/pubmed/commentcorrection/12391294-6828386, http://linkedlifedata.com/resource/pubmed/commentcorrection/12391294-7088155, http://linkedlifedata.com/resource/pubmed/commentcorrection/12391294-7215498, http://linkedlifedata.com/resource/pubmed/commentcorrection/12391294-7537406, http://linkedlifedata.com/resource/pubmed/commentcorrection/12391294-8216164, http://linkedlifedata.com/resource/pubmed/commentcorrection/12391294-8421494, http://linkedlifedata.com/resource/pubmed/commentcorrection/12391294-8725970, http://linkedlifedata.com/resource/pubmed/commentcorrection/12391294-8939850, http://linkedlifedata.com/resource/pubmed/commentcorrection/12391294-8980238, http://linkedlifedata.com/resource/pubmed/commentcorrection/12391294-9275178, http://linkedlifedata.com/resource/pubmed/commentcorrection/12391294-9368938, http://linkedlifedata.com/resource/pubmed/commentcorrection/12391294-9395480, http://linkedlifedata.com/resource/pubmed/commentcorrection/12391294-9438838, http://linkedlifedata.com/resource/pubmed/commentcorrection/12391294-9484596, http://linkedlifedata.com/resource/pubmed/commentcorrection/12391294-9524279, http://linkedlifedata.com/resource/pubmed/commentcorrection/12391294-9530494, http://linkedlifedata.com/resource/pubmed/commentcorrection/12391294-9592097, http://linkedlifedata.com/resource/pubmed/commentcorrection/12391294-9651552, http://linkedlifedata.com/resource/pubmed/commentcorrection/12391294-9662135, http://linkedlifedata.com/resource/pubmed/commentcorrection/12391294-9753324
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:day
29
pubmed:volume
99
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
14500-5
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
More...