| pubmed-article:12388444 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12388444 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:12388444 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:12388444 | lifeskim:mentions | umls-concept:C1565860 | lld:lifeskim |
| pubmed-article:12388444 | lifeskim:mentions | umls-concept:C1705323 | lld:lifeskim |
| pubmed-article:12388444 | lifeskim:mentions | umls-concept:C0010692 | lld:lifeskim |
| pubmed-article:12388444 | lifeskim:mentions | umls-concept:C0042034 | lld:lifeskim |
| pubmed-article:12388444 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:12388444 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:12388444 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:12388444 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:12388444 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:12388444 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:12388444 | pubmed:dateCreated | 2003-1-16 | lld:pubmed |
| pubmed-article:12388444 | pubmed:abstractText | The purpose of this study was to determine the role of cyclooxygenase-2 (COX-2) and its metabolites in lower urinary tract function after induction of acute (4 h), intermediate (48 h), or chronic (10 day) cyclophosphamide (CYP)-induced cystitis. Bladders were harvested from euthanized female rats for analyses. Conscious cystometry was used to assess the effects of a COX-2-specific inhibitor, 5,5-dimethyl-3-(3-fluorophenyl)-4-(4-methylsulfonyl)phenyl2(5H)-furanone (DFU, 5 mg/kg sc), a disubstituted furanone, in CYP-induced cystitis. COX-2 mRNA was increased in inflamed bladders after acute (12-fold) and chronic (9-fold) treatment. COX-2 protein expression in inflamed bladders paralleled COX-2 mRNA expression. Prostaglandin D2-methoxime expression in the bladder was significantly (P < or = 0.01) increased in acute (3-fold) and chronic (5.5-fold) cystitis. Prostaglandin E2 was significantly (P < or = 0.01) increased (2-fold) in the bladder with intermediate (1.7-fold) and chronic (2.6-fold) cystitis. COX-2-immunoreactive cell profiles were distributed throughout the inflamed bladder and coexpressed histamine immunoreactivity. Conscious cystometry in rats treated with CYP + DFU showed increased micturition intervals 4 and 48 h after CYP treatment and decreased intravesical pressures during filling and micturition compared with rats treated with CYP + vehicle. These studies suggest an involvement of urinary bladder COX-2 and its metabolites in altered micturition reflexes with CYP-induced cystitis. | lld:pubmed |
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| pubmed-article:12388444 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12388444 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12388444 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12388444 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12388444 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:12388444 | pubmed:issn | 0363-6119 | lld:pubmed |
| pubmed-article:12388444 | pubmed:author | pubmed-author:ZvaraPP | lld:pubmed |
| pubmed-article:12388444 | pubmed:author | pubmed-author:VizzardM AMA | lld:pubmed |
| pubmed-article:12388444 | pubmed:author | pubmed-author:MalleySS | lld:pubmed |
| pubmed-article:12388444 | pubmed:author | pubmed-author:HuV YVY | lld:pubmed |
| pubmed-article:12388444 | pubmed:author | pubmed-author:DattilioAA | lld:pubmed |
| pubmed-article:12388444 | pubmed:author | pubmed-author:FolsomJ BJB | lld:pubmed |
| pubmed-article:12388444 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12388444 | pubmed:volume | 284 | lld:pubmed |
| pubmed-article:12388444 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12388444 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12388444 | pubmed:pagination | R574-85 | lld:pubmed |
| pubmed-article:12388444 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:12388444 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12388444 | pubmed:articleTitle | COX-2 and prostanoid expression in micturition pathways after cyclophosphamide-induced cystitis in the rat. | lld:pubmed |
| pubmed-article:12388444 | pubmed:affiliation | Departments of Neurology, Anatomy and Neurobiology, and Surgery, University of Vermont College of Medicine, Burlington, Vermont 05405, USA. | lld:pubmed |
| pubmed-article:12388444 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12388444 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12388444 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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