| pubmed-article:12388382 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12388382 | lifeskim:mentions | umls-concept:C0175677 | lld:lifeskim |
| pubmed-article:12388382 | lifeskim:mentions | umls-concept:C0022646 | lld:lifeskim |
| pubmed-article:12388382 | lifeskim:mentions | umls-concept:C0022680 | lld:lifeskim |
| pubmed-article:12388382 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:12388382 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:12388382 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:12388382 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:12388382 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:12388382 | pubmed:dateCreated | 2002-11-11 | lld:pubmed |
| pubmed-article:12388382 | pubmed:abstractText | Kidney injury molecule-1 (Kim-1) is a type 1 membrane protein maximally upregulated in proliferating and dedifferentiated tubular cells after renal ischemia. Because epithelial dedifferentiation, proliferation, and local ischemia may play a role in the pathophysiology of autosomal dominant polycystic kidney disease, we investigated Kim-1 expression in a mouse model of this disease. In the Pkd2(WS25/-) mouse model for autosomal dominant polycystic kidney disease, cystic kidneys show markedly upregulated Kim-1 levels compared with noncystic control kidneys. Kim-1 is present in a subset of cysts of different sizes and segmental origins and in clusters of proximal tubules near cysts. Kim-1-expressing tubular cells show decreased complexity and quantity of basolateral staining for Na-K-ATPase. Other changes in polarity characteristic of ischemic injury are not present in Kim-1-expressing pericystic tubules. Polycystin-2 expression is preserved in Kim-1-expressing tubules. The interstitium surrounding Kim-1-expressing tubules shows high proliferative activity and staining for smooth muscle alpha-actin, characteristic of myofibroblasts. Although the functional role of the protein in cysts remains unknown, Kim-1 expression in tubules is strongly associated with partial dedifferentiation of epithelial cells and may play a role in the development of interstitial fibrosis. | lld:pubmed |
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| pubmed-article:12388382 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12388382 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12388382 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12388382 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12388382 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:12388382 | pubmed:issn | 1931-857X | lld:pubmed |
| pubmed-article:12388382 | pubmed:author | pubmed-author:BonventreJose... | lld:pubmed |
| pubmed-article:12388382 | pubmed:author | pubmed-author:ParkKwon... | lld:pubmed |
| pubmed-article:12388382 | pubmed:author | pubmed-author:SomloStefanS | lld:pubmed |
| pubmed-article:12388382 | pubmed:author | pubmed-author:KuehnE... | lld:pubmed |
| pubmed-article:12388382 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12388382 | pubmed:volume | 283 | lld:pubmed |
| pubmed-article:12388382 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12388382 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12388382 | pubmed:pagination | F1326-36 | lld:pubmed |
| pubmed-article:12388382 | pubmed:dateRevised | 2011-4-28 | lld:pubmed |
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| pubmed-article:12388382 | pubmed:meshHeading | pubmed-meshheading:12388382... | lld:pubmed |
| pubmed-article:12388382 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12388382 | pubmed:articleTitle | Kidney injury molecule-1 expression in murine polycystic kidney disease. | lld:pubmed |
| pubmed-article:12388382 | pubmed:affiliation | Renal Unit and Department of Medicine, Massachusetts General Hospital, Charlestown 02129, USA. | lld:pubmed |
| pubmed-article:12388382 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12388382 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12388382 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:18764 | entrezgene:pubmed | pubmed-article:12388382 | lld:entrezgene |
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