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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2002-11-11
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pubmed:abstractText |
Kidney injury molecule-1 (Kim-1) is a type 1 membrane protein maximally upregulated in proliferating and dedifferentiated tubular cells after renal ischemia. Because epithelial dedifferentiation, proliferation, and local ischemia may play a role in the pathophysiology of autosomal dominant polycystic kidney disease, we investigated Kim-1 expression in a mouse model of this disease. In the Pkd2(WS25/-) mouse model for autosomal dominant polycystic kidney disease, cystic kidneys show markedly upregulated Kim-1 levels compared with noncystic control kidneys. Kim-1 is present in a subset of cysts of different sizes and segmental origins and in clusters of proximal tubules near cysts. Kim-1-expressing tubular cells show decreased complexity and quantity of basolateral staining for Na-K-ATPase. Other changes in polarity characteristic of ischemic injury are not present in Kim-1-expressing pericystic tubules. Polycystin-2 expression is preserved in Kim-1-expressing tubules. The interstitium surrounding Kim-1-expressing tubules shows high proliferative activity and staining for smooth muscle alpha-actin, characteristic of myofibroblasts. Although the functional role of the protein in cysts remains unknown, Kim-1 expression in tubules is strongly associated with partial dedifferentiation of epithelial cells and may play a role in the development of interstitial fibrosis.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1931-857X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
283
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
F1326-36
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pubmed:dateRevised |
2011-4-28
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pubmed:meshHeading |
pubmed-meshheading:12388382-Amino Acid Sequence,
pubmed-meshheading:12388382-Animals,
pubmed-meshheading:12388382-Cell Adhesion Molecules,
pubmed-meshheading:12388382-Cell Division,
pubmed-meshheading:12388382-Epithelial Cells,
pubmed-meshheading:12388382-Fibroblasts,
pubmed-meshheading:12388382-Immunohistochemistry,
pubmed-meshheading:12388382-Kidney Tubules,
pubmed-meshheading:12388382-Membrane Proteins,
pubmed-meshheading:12388382-Mice,
pubmed-meshheading:12388382-Molecular Sequence Data,
pubmed-meshheading:12388382-Muscle, Smooth,
pubmed-meshheading:12388382-Polycystic Kidney, Autosomal Dominant,
pubmed-meshheading:12388382-Reference Values,
pubmed-meshheading:12388382-Sodium-Potassium-Exchanging ATPase,
pubmed-meshheading:12388382-Staining and Labeling,
pubmed-meshheading:12388382-TRPP Cation Channels,
pubmed-meshheading:12388382-Tissue Distribution
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pubmed:year |
2002
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pubmed:articleTitle |
Kidney injury molecule-1 expression in murine polycystic kidney disease.
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pubmed:affiliation |
Renal Unit and Department of Medicine, Massachusetts General Hospital, Charlestown 02129, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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