Source:http://linkedlifedata.com/resource/pubmed/id/12388257
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
2002-11-12
|
| pubmed:abstractText |
We monitored myocardial function in postinfarcted wild-type (WT) and transgenic (TG) mouse hearts with overexpression of the cardiac Na(+)/Ca(2+) exchanger. Five weeks after infarction, cardiac function was better maintained in TG than WT mice [left ventricular (LV) systolic pressure: WT, 41 +/- 2; TG, 58 +/- 3 mmHg; P < 0.05; maximum rising rate of LV pressure (+dP/dt(max)): WT, 3,750 +/- 346; TG, 5,075 +/- 334 mmHg/s; P < 0.05]. The isometric contractile response to beta-adrenergic stimulation was greater in papillary muscles from TG than WT mice (WT, 13.2 +/- 0.9; TG, 16.3 +/- 1.0 mN/mm(2) at 10(-4) M isoproterenol). The sarcoplasmic reticulum (SR) Ca(2+) content investigated by rapid cooling contractures in papillary muscles was greater in TG than WT mouse hearts. We conclude that myocardial function is better preserved in TG mice 5 wk after infarction, which results from enhanced SR Ca(2+) content via overexpression of the Na(+)/Ca(2+) exchanger.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0363-6135
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
283
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
H2466-71
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:12388257-Adrenergic beta-Agonists,
pubmed-meshheading:12388257-Animals,
pubmed-meshheading:12388257-Calcium,
pubmed-meshheading:12388257-Disease Models, Animal,
pubmed-meshheading:12388257-Disease Progression,
pubmed-meshheading:12388257-Electrocardiography,
pubmed-meshheading:12388257-Gene Expression,
pubmed-meshheading:12388257-Heart Rate,
pubmed-meshheading:12388257-Hemodynamics,
pubmed-meshheading:12388257-Heterozygote,
pubmed-meshheading:12388257-Isoproterenol,
pubmed-meshheading:12388257-Mice,
pubmed-meshheading:12388257-Mice, Transgenic,
pubmed-meshheading:12388257-Myocardial Contraction,
pubmed-meshheading:12388257-Myocardial Infarction,
pubmed-meshheading:12388257-Myocardium,
pubmed-meshheading:12388257-Sarcoplasmic Reticulum,
pubmed-meshheading:12388257-Sodium-Calcium Exchanger,
pubmed-meshheading:12388257-Ventricular Dysfunction, Left
|
| pubmed:year |
2002
|
| pubmed:articleTitle |
Overexpression of Na+/Ca2+ exchanger gene attenuates postinfarction myocardial dysfunction.
|
| pubmed:affiliation |
Cardiovascular Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115, USA.
|
| pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.
|