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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
20
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pubmed:dateCreated |
2002-10-16
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pubmed:abstractText |
De novo chromatin assembly into regularly spaced nucleosomal arrays is essential for eukaryotic genome maintenance and inheritance. The Anti-Silencing Function 1 protein (ASF1) has been shown to be a histone chaperone, participating in DNA-replication-coupled nucleosome assembly. We show that mutations in the Drosophila asf1 gene derepress silencing at heterochromatin and that the ASF1 protein has a cell cycle-specific nuclear and cytoplasmic localization. Furthermore, using both genetic and biochemical methods, we demonstrate that ASF1 interacts with the Brahma (SWI/SNF) chromatin-remodelling complex. These findings suggest that ASF1 plays a crucial role in both chromatin assembly and SWI/SNF-mediated chromatin remodelling.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/12381660-10385622,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12381660-10589670,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12381660-10591219,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12381660-10601025,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12381660-10736259,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12381660-10759893,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12381660-10809665,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12381660-11151674,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12381660-11250135,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12381660-11331758,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12381660-11404324,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12381660-11412995,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12381660-11420721,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12381660-11533245,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12381660-11544176,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12381660-11980720,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12381660-12093919,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12381660-1350533,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12381660-1982376,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12381660-7664737,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12381660-7758950,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12381660-8223268,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12381660-8649423,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12381660-8825476,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/12381660-9735357
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0890-9369
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2621-6
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:12381660-Animals,
pubmed-meshheading:12381660-Cell Cycle Proteins,
pubmed-meshheading:12381660-Chromosomal Proteins, Non-Histone,
pubmed-meshheading:12381660-Crosses, Genetic,
pubmed-meshheading:12381660-Drosophila Proteins,
pubmed-meshheading:12381660-Drosophila melanogaster,
pubmed-meshheading:12381660-Eye Color,
pubmed-meshheading:12381660-Female,
pubmed-meshheading:12381660-Gene Deletion,
pubmed-meshheading:12381660-Gene Silencing,
pubmed-meshheading:12381660-Heterozygote,
pubmed-meshheading:12381660-Male,
pubmed-meshheading:12381660-Molecular Chaperones,
pubmed-meshheading:12381660-Mutation,
pubmed-meshheading:12381660-Nucleosomes,
pubmed-meshheading:12381660-Protein Transport,
pubmed-meshheading:12381660-Transcription Factors
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pubmed:year |
2002
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pubmed:articleTitle |
Histone chaperone ASF1 cooperates with the Brahma chromatin-remodelling machinery.
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pubmed:affiliation |
Department of Zoology and Animal Biology, University of Geneva, 1211 Geneva 4, Switzerland.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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