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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1976-1-10
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pubmed:abstractText |
Ten laboratories took part in an international study of the proposed standard for human thrombin. A freeze-dried preparation (coded 70/157) was shown, using clotting time tests, to be suitable to serve as a standard for the assay of human and bovine thrombin preparations. The study shows that assay variation within laboratories was much less than between laboratories. The preparation was stable, having a negligible estimated loss of potency after ten years under the recommended storage conditions (--20 degrees C in the dark). Each ampoule of the standard was assigned a potency of 100 units of thrombin activity, and one unit was defined as the activity contained in 0.0853 mg of the freeze-dried preparation. It was agreed by the participants in the study and by the International Committee on Thrombosis and Haemostasis (Vienna, 1973) that the thrombin preparation coded 70/157 is suitable to serve as an international standard for human thrombin.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0340-5338
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
30
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pubmed:volume |
34
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3-18
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:1237945-Animals,
pubmed-meshheading:1237945-Cattle,
pubmed-meshheading:1237945-Drug Stability,
pubmed-meshheading:1237945-Drug Storage,
pubmed-meshheading:1237945-Fibrinogen,
pubmed-meshheading:1237945-Freeze Drying,
pubmed-meshheading:1237945-Great Britain,
pubmed-meshheading:1237945-Humans,
pubmed-meshheading:1237945-Indicators and Reagents,
pubmed-meshheading:1237945-International Cooperation,
pubmed-meshheading:1237945-Laboratories,
pubmed-meshheading:1237945-Temperature,
pubmed-meshheading:1237945-Thrombin,
pubmed-meshheading:1237945-Weights and Measures
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pubmed:year |
1975
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pubmed:articleTitle |
Standard for human thrombin.
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pubmed:publicationType |
Journal Article
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