|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
6
|
|
pubmed:dateCreated |
2002-10-10
|
|
pubmed:abstractText |
We investigated the antitumor activity of the nucleoside analog 1-(2-deoxy-2-fluoro-4-thio-beta-D-arabinofuranosyl)cytosine (4'-thio-FAC) in peritoneal dissemination models of gastrointestinal cancers. Oral administration of 4'-thio-FAC showed a marked effect on the development of ascites and on the survival of nude mice implanted with the highly metastatic MKN-45-P gastric cancer cells into the peritoneal cavity. The toxic effect was observed at a dose of 15 mg/kg, however, no toxicity was observed at a dose of 10 mg/kg with excellent antitumor activity. We established another highly metastatic cell line HCT-15-P by serial intraperitoneal passage of the colon cancer cell line HCT-15. In the HCT-15-P model, 4'-thio-FAC showed an inhibitory effect of peritoneal dissemination and an increase in the life span at a dose of 10 mg/kg. On the other hand, oral administration of 5-fluorouracil (5-FU) and 5'-deoxy-5-fluorouridine (5'-DFUR) did not show an increase in the life span of mice at a dose of 10 mg/kg. In conclusion, 4'-thio-FAC is a promising therapeutic agent for use against peritoneal dissemination of gastrointestinal cancers.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
1021-335X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
9
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1319-22
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:12375041-Adenocarcinoma,
pubmed-meshheading:12375041-Administration, Oral,
pubmed-meshheading:12375041-Animals,
pubmed-meshheading:12375041-Antimetabolites, Antineoplastic,
pubmed-meshheading:12375041-Antineoplastic Agents,
pubmed-meshheading:12375041-Body Weight,
pubmed-meshheading:12375041-Cell Division,
pubmed-meshheading:12375041-Colonic Neoplasms,
pubmed-meshheading:12375041-Cytarabine,
pubmed-meshheading:12375041-Disease Models, Animal,
pubmed-meshheading:12375041-Female,
pubmed-meshheading:12375041-Floxuridine,
pubmed-meshheading:12375041-Fluorouracil,
pubmed-meshheading:12375041-Humans,
pubmed-meshheading:12375041-Mice,
pubmed-meshheading:12375041-Mice, Nude,
pubmed-meshheading:12375041-Neoplasm Transplantation,
pubmed-meshheading:12375041-Peritoneal Neoplasms,
pubmed-meshheading:12375041-Stomach Neoplasms,
pubmed-meshheading:12375041-Survival Rate,
pubmed-meshheading:12375041-Tumor Cells, Cultured
|
|
pubmed:articleTitle |
Potent antitumor effect of 1-(2-deoxy-2-fluoro-4-thio-beta-D-arabinofuranosyl)cytosine on peritoneal dissemination models of gastrointestinal cancers.
|
|
pubmed:affiliation |
Biochemicals Division, Yamasa Corporation, Choshi, Chiba 288-0056, Japan. miura@yamasa.com
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|
