Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2003-3-4
pubmed:abstractText
The purpose of this study was to use high resolution magnetic resonance imaging (HR-MRI) combined with structure analysis to investigate the trabecular structure of the human proximal femur and to compare this technique with bone mineral density (BMD) using dual energy X-ray absorptiometry (DXA) in the prediction of bone strength in vitro. Thirty-one fresh human proximal femur specimens were examined with HR-MRI using a T1-weighted 3D spinecho-sequence in a coronal plane (voxel size: 0.195 x 0.195 x 0.9 mm and 0.195 x 0.195 x 0.3 mm). In these images structure parameters analogous to standard bone histomorphometry were obtained in a femoral head, neck, and trochanteric region of interest (ROI). In addition, BMD measurements were obtained using DXA and finally, all specimens were tested biomechanically in a materials testing machine, and maximum compressive strength (MCS) was determined. Correlations between BMD and MCS were significant (p <0.01) with R-values up to 0.74. Correlating structure parameters and MCS R-values up to 0.69 (P <0.01) were obtained. Using multivariate regression analysis, combining structure parameters and BMD, improved correlations versus MCS substantially (up to R = 0.93; P <0.01). In conclusion, this study showed that in an experimental setting, structure parameters determined in high resolution MR images of the proximal femur correlated significantly with bone strength. The highest correlations, however, were obtained combining BMD and structure measures.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0171-967X
pubmed:author
pubmed:issnType
Print
pubmed:volume
72
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
156-65
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Structure analysis of high resolution magnetic resonance imaging of the proximal femur: in vitro correlation with biomechanical strength and BMD.
pubmed:affiliation
Department of Radiology, Technische Universität München, Munich, Germany. tmlink@roe.med.tu-muenchen.de
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't